WNT2B

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WNT2B
Identifiers
Aliases WNT2B, WNT13, Wnt family member 2B
External IDs MGI: 1261834 HomoloGene: 22526 GeneCards: WNT2B
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WNT2B
Genomic location for WNT2B
Band 1p13.2 Start 112,466,541 bp[1]
End 112,530,165 bp[1]
RNA expression pattern
PBB GE WNT2B 206458 s at fs.png

PBB GE WNT2B 206459 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024494
NM_001291880
NM_004185

NM_009520

RefSeq (protein)

NP_001278809
NP_004176
NP_078613

NP_033546

Location (UCSC) Chr 1: 112.47 – 112.53 Mb Chr 1: 104.95 – 104.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-2b (formerly Wnt13[5]) is a protein that in humans is encoded by the WNT2B gene.[6][7][8]

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134245 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027840 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. PMID 12490564. 
  6. ^ Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID 8761309. 
  7. ^ Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466. 
  8. ^ a b "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B". 

Further reading[edit]