WNT3

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WNT3
Identifiers
AliasesWNT3, INT4, TETAMS, Wnt family member 3
External IDsMGI: 98955 HomoloGene: 22527 GeneCards: WNT3
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for WNT3
Genomic location for WNT3
Band17q21.31-q21.32Start46,762,506 bp[1]
End46,833,154 bp[1]
RNA expression pattern
PBB GE WNT3 221455 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030753

NM_009521

RefSeq (protein)

NP_110380

NP_033547

Location (UCSC)Chr 17: 46.76 – 46.83 MbChr 11: 103.77 – 103.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.[6]

References[edit]

  1. ^ a b c ENSG00000277641, ENSG00000277626 GRCh38: Ensembl release 89: ENSG00000108379, ENSG00000277641, ENSG00000277626 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000125 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
  6. ^ a b "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links[edit]

Further reading[edit]