WNT3

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WNT3
Identifiers
Aliases WNT3, INT4, TETAMS, Wnt family member 3
External IDs MGI: 98955 HomoloGene: 22527 GeneCards: 7473
Genetically Related Diseases
Disease Name References
Parkinson's disease
RNA expression pattern
PBB GE WNT3 221455 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030753

NM_009521

RefSeq (protein)

NP_110380.1

NP_033547.1

Location (UCSC) Chr 17: 46.76 – 46.83 Mb Chr 11: 103.77 – 103.82 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.[2]

References[edit]

  1. ^ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403. 
  2. ^ a b "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3". 

External links[edit]

Further reading[edit]