WNT7A

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WNT7A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWNT7A, Wnt family member 7A
External IDsMGI: 98961 HomoloGene: 20969 GeneCards: WNT7A
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for WNT7A
Genomic location for WNT7A
Band3p25.1Start13,816,258 bp[1]
End13,880,121 bp[1]
RNA expression pattern
PBB GE WNT7A 210248 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004625

NM_009527
NM_001363757

RefSeq (protein)

NP_004616

NP_033553
NP_001350686

Location (UCSC)Chr 3: 13.82 – 13.88 MbChr 6: 91.36 – 91.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.[5][6][7]

Function[edit]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154764 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030093 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y (Dec 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet. 74 (1–2): 149–52. doi:10.1159/000134404. PMID 8893824.
  6. ^ Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL (Jun 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene. 189 (1): 25–9. doi:10.1016/S0378-1119(96)00808-6. PMID 9161407.
  7. ^ a b "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A".

Further reading[edit]