WNT7B

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WNT7B
Identifiers
AliasesWNT7B, Wnt family member 7B
External IDsMGI: 98962 HomoloGene: 22531 GeneCards: WNT7B
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for WNT7B
Genomic location for WNT7B
Band22q13.31Start45,920,362 bp[1]
End45,977,129 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_058238

NM_001163633
NM_001163634
NM_009528

RefSeq (protein)

NP_478679

NP_001157105
NP_001157106
NP_033554

Location (UCSC)Chr 22: 45.92 – 45.98 MbChr 15: 85.54 – 85.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene.[5][6][7][8]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188064 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022382 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (Jun 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res. 54 (10): 2615–21. PMID 8168088.
  6. ^ van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 288–9. doi:10.1159/000134600. PMID 9284940.
  7. ^ Kirikoshi H, Sekihara H, Katoh M (Sep 2001). "Molecular cloning and characterization of human WNT7B". Int J Oncol. 19 (4): 779–83. doi:10.3892/ijo.19.4.779. PMID 11562755.
  8. ^ a b "Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B".

Further reading[edit]