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WPXR refers to:

  • WLKU, an FM radio station (98.9 MHz) licensed to Rock Island, Illinois, United States, which held the call sign WPXR-FM from March 18, 1987 to July 28, 1995
  • WPXR-TV, a television station (channel 36 digital/38 virtual) licensed to Roanoke, Virginia, United States