WRNIP1

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WRNIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWRNIP1, WHIP, bA420G6.2, Werner helicase interacting protein 1
External IDsMGI: 1926153 HomoloGene: 10592 GeneCards: WRNIP1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for WRNIP1
Genomic location for WRNIP1
Band6p25.2Start2,765,414 bp[1]
End2,786,952 bp[1]
RNA expression pattern
PBB GE WRNIP1 218015 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020135
NM_130395

NM_030215

RefSeq (protein)

NP_064520
NP_569079

NP_084491

Location (UCSC)Chr 6: 2.77 – 2.79 MbChr 13: 32.8 – 32.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATPase WRNIP1 is an enzyme that in humans is encoded by the WRNIP1 gene.[5][6]

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.[6]

Interactions[edit]

WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124535 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021400 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.
  6. ^ a b "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

Further reading[edit]

External links[edit]