WTAP (gene)

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WTAP
Identifiers
Aliases WTAP, Mum2, Wilms tumor 1 associated protein, WT1 associated protein
External IDs MGI: 1926395 HomoloGene: 68422 GeneCards: WTAP
RNA expression pattern
PBB GE WTAP gnf1h04654 at fs.png

PBB GE WTAP 210285 x at fs.png

PBB GE WTAP 203137 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001113532
NM_001113533
NM_175394

RefSeq (protein)

NP_001107004.1
NP_780603.1
NP_001107004
NP_001107005
NP_780603

Location (UCSC) Chr 6: 159.73 – 159.76 Mb Chr 17: 12.97 – 12.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.[3][4][5]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.[5]

Interactions[edit]

WTAP (gene) has been shown to interact with WT1.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527. 
  4. ^ a b Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet. 9 (15): 2231–9. doi:10.1093/oxfordjournals.hmg.a018914. PMID 11001926. 
  5. ^ a b "Entrez Gene: WTAP Wilms tumor 1 associated protein". 

Further reading[edit]