WYFR was descended from W1XAL, an experimental shortwave station in that was granted its license in 1927 and broadcast from Boston until 1936 when the station moved to Scituate, Massachusetts. In 1939 the call letters were changed to WRUL and initially served as an educational station broadcasting university lectures. During World War II it became a propaganda station and was leased by the US government from 1942 until the end of the war. The station became WNYW in 1966.
In 1973, it was purchased by Family Stations, Inc, and began broadcasting as WYFR on October 20, 1973. The call sign stands for We're Your Family Radio. The station built new transmitters in Okeechobee, Florida in 1977, and closed the Scituate site in 1979. In mid-2013 Family Radio announced it would be permanently closing WYFR on June 30, 2013. The station did in fact close but was purchased by WRMI and brought back to the air in December 2013.