The largest area, known as Walker Bay, stretches from the Klein River estuary to De Kelders at Gansbaai.
Access to the reserve is via Mierkom or Walker Bay Fishing trail (through Stanford); De Kelders (Die Plaat) or Uilkraalsmond. An entry permit is required and can be obtained at the gatehouses at De Kelders, Uilkraalsmond and Walker Bay Fishing Trail. Alternatively, permits can be obtained from the Walker Bay Nature Reserve office at 16th, 17th Avenue, Voëlklip, Hermanus during office hours (Monday to Friday 08:00–16:00). The reserve is open daily between 07:00 and 19:00.
Walker Bay Nature Reserve offers no accommodation but day visitors are welcome to enjoy a variety of day hikes along the coast. Angling, swimming and picnicking are permitted, but please note that the sea can be rough and dangerous. Fires and overnight camping are not allowed. Marine Coastal Management regulations apply to the removal of bait and other marine organisms. Permits for marine angling are available at post offices.