Jones attended Holmes Community College for two seasons, where he was named Mississippi Junior College Player of the Year by the Jackson Clarion-Ledger in 1994. Then 6′5″ and 265 pounds, Jones played both offensive tackle and tight end. He allowed one sack in two seasons.
Jones was drafted by the Seahawks in the first round and sixth overall in the 1997 NFL Draft. He started every game in which he played, beginning with his rookie season. Jones was a member of the 2005 Seahawks team that lost Super Bowl XL to the Pittsburgh Steelers. In 2006, Jones topped the list of the 101 best NFL players by the Sporting News.
Jones was a nine-time Pro Bowl selection and seven-time All-Pro. Jones was perhaps the best at his position in the NFL during the early part of the decade, exemplified by being voted to the NFL's 2000s All Decade Team. From 1998 through 2000, he helped Ricky Watters achieve three consecutive 1,000-yard seasons for the Seahawks and, later, paved the way for Shaun Alexander's NFL record-setting success.
Walter Jones was recognized by John Madden as the best player in the NFL in 2004 in a broadcast. Madden recognized Jones in numerous broadcasts as the best left tackle in the NFL and possibly one of the best of all time.
Seahawks coach Mike Holmgren called Jones the best offensive player he had ever coached.
On Thanksgiving 2008, Walter Jones succumbed to a knee injury playing against the Cowboys in his 180th and final game. The injury required microfracture surgery to repair and immediately ended his season. Jones tried to play again in 2009, but was unsuccessful. On October 28, 2009, Jones was placed on injured reserve by the Seahawks. In a press conference the same day, Jones stated his intention to play in 2010. On April 29, 2010, Jones announced on his Twitter account that he would retire.
The Seahawks announced the retirement of his number, 71, and governor Christine Gregoire declared April 30 to be "Walter Jones Day" in the state of Washington.
On December 5, 2010, in a game versus the Carolina Panthers, in front of a crowd of over 66,000, the Seahawks honored the career of Jones by retiring his #71 jersey. This was only the third player number (#80 Steve Largent and #96 Cortez Kennedy) to be retired by the Seahawks (they have also retired #12 in honor of the fans).
On January 8, 2011, Jones lifted the 12th Man flag at Qwest Field before the Seahawks' wild card matchup against the New Orleans Saints. The 7–9 Seahawks went on to defeat the defending Super Bowl champion Saints 41–36.