The band has stated that the song is about the "state of the world due to war, people dying, people living in fear, and the power of corporations, amongst other concerns." It was written after their trip to the Congo, making it the last song written for Chuck ("Noots" was originally going to be track 3 on the album, but was cut right after "We're All To Blame" was recorded).
The song has received universal critical acclaim. Fox83 of Sputnikmusic called the song an "impressive approach lyrically" and said "If System of a Down's "Chop Suey!" had never been released then this could be leaning on originality. Aside from these irritations, 'We're All to Blame' is a great effort, and deserves its place on 'Chuck.'"Entertainment Weekly said "It may sound heinous on paper, but trust us, the first single, 'We're All To Blame,' is far better than it has a right to be."IGN gave a very positive recommendation of the song, saying "'We're All To Blame' is, bar none, the single best song Sum 41 has ever written and performed. A hard-hitting metal ballad that comments on global greed and its horrible consequences, the song not only stands out on Chuck, but it stands out as the high point of Sum 41's entire catalogue."