Weber–Christian disease

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Weber–Christian disease
Classification and external resources
Specialty rheumatology
ICD-10 M35.6
ICD-9-CM 729.30
DiseasesDB 14055
eMedicine ped/2429
MeSH D010201

Weber–Christian disease, also known as relapsing febrile nodular nonsuppurative panniculitis, is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin.[1]

It is type of panniculitis.[2] It is a rare disease seen in females 30–60 years of age. It is a recurring inflammation of fatty layers of tissue present beneath the skin. Clinical course is characterised by exacerbations and remissions. Lesions are bilaterally symmetrical and are usually seen in the lower legs.


It is named for Frederick Parkes Weber and Henry Asbury Christian.[3][4][5]

See also[edit]


  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ "Weber-Christian disease" at Dorland's Medical Dictionary
  3. ^ Weber–Christian disease at Who Named It?
  4. ^ F. P. Weber. A case of relapsing non-suppurative nodular panniculitis, showing phagocytosis of subcutaneous fat-cells by macrophages. British Journal of Dermatology and Syphilis, Oxford, 1925, 37: 301-311. doi:10.1111/j.1365-2133.1925.tb10003.x
  5. ^ H. A. Christian. Relapsing febrile nodular nonsuppurative panniculitis. Archives of Internal Medicine, Chicago, 1928, 42: 338-351. doi:10.1001/archinte.1928.00020020026004