Wee1-like protein kinase

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See also: Wee1
WEE1 G2 checkpoint kinase
PBB Protein WEE1 image.jpg
PDB rendering based on 1x8b.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols WEE1 ; WEE1A; WEE1hu
External IDs OMIM193525 MGI103075 HomoloGene31152 ChEMBL: 5491 GeneCards: WEE1 Gene
EC number
Species Human Mouse
Entrez 7465 22390
Ensembl ENSG00000166483 ENSMUSG00000031016
UniProt P30291 P47810
RefSeq (mRNA) NM_001143976 NM_009516
RefSeq (protein) NP_001137448 NP_033542
Location (UCSC) Chr 11:
9.57 – 9.59 Mb
Chr 7:
110.12 – 110.14 Mb
PubMed search [1] [2]

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[1]


This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[2]


Wee1-like protein kinase has been shown to interact with YWHAB[3] and PIN1.[4]


  1. ^ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature 353 (6339): 80–3. doi:10.1038/353080a0. PMID 1840647. 
  2. ^ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)". 
  3. ^ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. (UNITED STATES) 11 (4): 211–9. ISSN 1044-9523. PMID 10775038. 
  4. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. (UNITED STATES) 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405. 

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