Wen-Hsiung Li

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Wen-Hsiung Li
Born
Wen Hsiung Li

(1942-09-22) September 22, 1942 (age 76)
NationalityTaiwanese
CitizenshipTaiwanese-American
Alma materBrown University, Providence, RI, USA
National Central University, Taiwan
Chung-Yuang College of Science and Engineering, Taiwan
Known forMale-Driven Evolution[1][2][3]
Molecular clock[4]
Genomics[5]
AwardsBalzan Prize for Genetics and Evolution (2003)[6]
Mendel Medal (2009)[7]
Scientific career
FieldsMathematics
Genetics
Evolutionary Biology
Genomics
InstitutionsUniversity of Chicago
Academia Sinica
University of Texas
University of Wisconsin-Madison
ThesisMathematical Studies On Mutational Damages In Finite Populations (1972)
Doctoral advisorWendell Fleming
Other academic advisorsMasatoshi Nei
WebsiteLi Laboratory at University of Chicago
Wen Hsiung Li Profile at Academia Sinica

Wen-Hsiung Li (Chinese: 李文雄; born 1942) is a Taiwanese-American scientist working in the fields of molecular evolution, population genetics, and genomics. He is currently the James Watson Professor of Ecology and Evolution at the University of Chicago and a Principal Investigator at the Institute of Information Science and Genomics Research Center, Academia Sinica, Taiwan.

Biography[edit]

Li was born in 1942 in Taiwan. In 1968 he received a M.S. in geophysics from National Central University. In 1972 he received his Ph.D in applied mathematics at Brown University in Providence, Rhode Island. From 1972 to 1973 he was a post-doctoral researcher at the University of Wisconsin Madison (genetics), working with James F. Crow. In 1973 he moved to the University of Texas, where he was appointed as a professor in 1984. Since 1998 he has been a professor at The University of Chicago.

Scientific contributions[edit]

Professor Li is best known for his studies on the molecular clock (i.e. rates and patterns of DNA sequence evolution) and on the patterns and consequences of gene duplication.

In 2003, he received the international Balzan Prize for his contribution to genetics and evolutionary biology, and was elected to the National Academy of Sciences, who cited his role in "establishing theoretical foundations for molecular phylogenetics and evolutionary genomics"[1]. He is the author of the first texts in the field of molecular evolution, Molecular Evolution and Fundamentals of Molecular Evolution (co-authored with Dan Graur), and an author on more than 200 peer-reviewed publications.

Honors[edit]

Selected publications[edit]

  • Chu, T. -C.; Lu, C. -H.; Liu, T.; Lee, G. C.; Li, W. -H.; Shih, A. C. -C. (2013). "Assembler for de novo assembly of large genomes". Proceedings of the National Academy of Sciences. 110 (36): E3417. doi:10.1073/pnas.1314090110. PMC 3767511.
  • Gu, Z.; Steinmetz, L. M.; Gu, X.; Scharfe, C.; Davis, R. W.; Li, W. H. (2003). "Role of duplicate genes in genetic robustness against null mutations". Nature. 421 (6918): 63–6. doi:10.1038/nature01198. PMID 12511954.
  • Makova, K. D.; Li, W. H. (2002). "Strong male-driven evolution of DNA sequences in humans and apes". Nature. 416 (6881): 624–6. doi:10.1038/416624a. PMID 11948348.
  • Li, W. H.; Gu, Z.; Wang, H.; Nekrutenko, A. (2001). "Evolutionary analyses of the human genome". Nature. 409 (6822): 847–9. doi:10.1038/35057039. PMID 11237007.
  • Tan, Y.; Li, W. H. (1999). "Vision: Trichromatic vision in prosimians". Nature. 402 (6757): 36. doi:10.1038/46947. PMID 10573416.
  • Shyue, S.; Hewett-Emmett, D.; Sperling, H.; Hunt, D.; Bowmaker, J.; Mollon, J.; Li, W.H. (1995). "Adaptive evolution of color vision genes in higher primates". Science. 269 (5228): 1265–7. doi:10.1126/science.7652574. PMID 7652574.
  • Shimmin, L. C.; Chang, B. H. J.; Li, W. H. (1993). "Male-driven evolution of DNA sequences". Nature. 362 (6422): 745–7. doi:10.1038/362745a0. PMID 8469284.
  • Graur, D.; Hide, W. A.; Li, W. H. (1991). "Is the guinea-pig a rodent?". Nature. 351 (6328): 649–52. doi:10.1038/351649a0. PMID 2052090.
  • Graur, D. A. N.; Li, W.H. (1991). "Neutral mutation hypothesis test". Nature. 354 (6349): 114. doi:10.1038/354114e0.
  • Wolfe, K. H.; Sharp, P. M.; Li, W. H. (1989). "Mutation rates differ among regions of the mammalian genome". Nature. 337 (6204): 283–5. doi:10.1038/337283a0. PMID 2911369.
  • Gouy, M.; Li, W. H. (1989). "Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree". Nature. 339 (6220): 145–7. doi:10.1038/339145a0. PMID 2497353.
  • Sharp, P.; Shields, D.; Wolfe, K.; Li, W.H. (1989). "Chromosomal location and evolutionary rate variation in enterobacterial genes". Science. 246 (4931): 808–10. doi:10.1126/science.2683084. PMID 2683084.
  • Sharp, P. M.; Li, W.H. (1988). "Understanding the origins of AIDS viruses". Nature. 336 (6197): 315. doi:10.1038/336315a0. PMID 3194016.
  • Li, W. H.; Tanimura, M. (1987). "The molecular clock runs more slowly in man than in apes and monkeys". Nature. 326 (6108): 93–6. doi:10.1038/326093a0. PMID 3102974.
  • Li, W. H.; Gojobori, T.; Nei, M. (1981). "Pseudogenes as a paradigm of neutral evolution". Nature. 292 (5820): 237–9. doi:10.1038/292237a0. PMID 7254315.
  • Nei, M.; Li, W. H. (1979). "Mathematical model for studying genetic variation in terms of restriction endonucleases". Proceedings of the National Academy of Sciences. 76 (10): 5269–73. doi:10.1073/pnas.76.10.5269. PMC 413122. PMID 291943.

Selected books[edit]

  • Li, W.-H. (2006). Molecular Evolution. Sinauer. ISBN 0-87893-480-4.
  • Dan Graur; Wen-Hsiung Li (2000). Fundamentals of Molecular Evolution: Second Edition. Sinauer Associates, Inc.

References[edit]

  1. ^ Shimmin, L. C.; Chang, B. H. J.; Li, W. H. (1993). "Male-driven evolution of DNA sequences". Nature. 362 (6422): 745–7. doi:10.1038/362745a0. PMID 8469284.
  2. ^ Makova, K. D.; Li, W. H. (2002). "Strong male-driven evolution of DNA sequences in humans and apes". Nature. 416 (6881): 624–6. doi:10.1038/416624a. PMID 11948348.
  3. ^ "Males' DNA propels evolution, study says". Chicago Tribune. Retrieved June 1, 2014.
  4. ^ Lewin, R. (1985). "Molecular clocks scrutinized". Science. 228 (4699): 571. doi:10.1126/science.3983640.
  5. ^ Li, W. H.; Gu, Z.; Wang, H.; Nekrutenko, A. (2001). "Evolutionary analyses of the human genome". Nature. 409 (6822): 847–9. doi:10.1038/35057039. PMID 11237007.
  6. ^ "Balzan Prize for Genetics and Evolution". International Balzan Prize Foundation website. International Balzan Prize Foundation. Retrieved February 8, 2014.
  7. ^ "Mendel Medal". The Genetics Society website. The Genetics Society. Retrieved February 8, 2014.

External links[edit]