Wendy Bickmore

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Wendy Bickmore

Wendy Bickmore Royal Society.jpg
Wendy Bickmore at the Royal Society admissions day in London, July 2017
Born
Wendy Anne Bickmore

(1961-07-28) 28 July 1961 (age 60)[1]
NationalityBritish
EducationChichester High School For Girls[1]
Alma materUniversity of Oxford (BA)
University of Edinburgh (PhD)
Awards
Scientific career
FieldsGenetics
Genomics
Institutions
ThesisMolecular analysis of DNA sequences from the human Y chromosome
Doctoral advisorHoward Cooke[3]
InfluencesAdrian Bird[3][4]
Websiteed.ac.uk/mrc-human-genetics-unit/research/bickmore-group

Wendy Anne Bickmore CBE FRS FMedSci FRSE (born 28 July 1961[5]) is a British genome biologist known for her research on the organisation of genomic material in cells.

Early life and education[edit]

Bickmore was born at Shoreham-by-Sea on 28 July 1961 to Beryl and Keith Bickmore.[5] She was educated at Chichester High School For Girls[5] and obtained an undergraduate Bachelor of Arts degree in biochemistry from the University of Oxford and her PhD from the University of Edinburgh for research analysing nucleic acid sequences from the Y chromosome of humans supervised by Howard Cooke[3] and Adrian Bird.[4]

Career[edit]

Bickmore’s interest in science began as a teen being influenced by her biology teacher and her parents who were keen amateur gardeners. Her interest in biochemistry was confirmed having read ‘The Chemistry of Life’ by Steven Rose[6] and she went on to study biochemistry at university. Her Ph.D. research examined DNA sequences from the Y chromosome in humans.[7] She was an independent fellow at the Lister Institute of Preventive Medicine from 1991 until 1996.[8]

Research and career[edit]

Her work has focused on how DNA, chromosomes and specific genes are organised and packaged in the cell nucleus,[9] how this process is regulated during development to facilitate the expression of genes, and how aberrant genome organisation is linked to disease.[10][11][12][13] In 2020, she was recognized for her research examining the likelihood that people will develop serious symptoms of the COVID-19 disease.[14]

Bickmore was president of The Genetics Society from 2015 until 2018.[15] As of 2021, she is director of the MRC Human Genetics Unit at the University of Edinburgh.[16][8] She is a member of the editorial board for Genes & Development.[17]

Selected publications[edit]

  • Croft, Jenny A.; Bridger, Joanna M.; Boyle, Shelagh; Perry, Paul; Teague, Peter; Bickmore, Wendy A. (14 June 1999). "Differences in the Localization and Morphology of Chromosomes in the Human Nucleus". Journal of Cell Biology. 145 (6): 1119–1131. doi:10.1083/jcb.145.6.1119. ISSN 0021-9525.
  • Fraser, Peter; Bickmore, Wendy (May 2007). "Nuclear organization of the genome and the potential for gene regulation". Nature. 447 (7143): 413–417. doi:10.1038/nature05916. ISSN 1476-4687.
  • Finlan, Lee E.; Sproul, Duncan; Thomson, Inga; Boyle, Shelagh; Kerr, Elizabeth; Perry, Paul; Ylstra, Bauke; Chubb, Jonathan R.; Bickmore, Wendy A. (21 March 2008). "Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells". PLOS Genetics. 4 (3): e1000039. doi:10.1371/journal.pgen.1000039. ISSN 1553-7404.

Awards and honours[edit]

Bickmore was awarded EMBO Membership in 2001,[2] elected a Fellow of the Royal Society of Edinburgh (FRSE) in 2005[5] and elected a Fellow of the Academy of Medical Sciences in 2005 (FMedSci).[18] She was elected a Fellow of the Royal Society (FRS) in 2017.[19] She was appointed Commander of the Order of the British Empire (CBE) in the 2021 New Year Honours for services to biomedical sciences and women in science.[20]

Personal life[edit]

She is a member of the organisation Trees for Life which is working to restore the forest in the Highlands of Scotland.[21]

References[edit]

  1. ^ a b c Anon (2017). "Bickmore, Prof. Wendy Anne". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.274935. (subscription or UK public library membership required) (subscription required)
  2. ^ a b Anon (2001). "EMBO member: Wendy Bickmore". people.embo.org. Heidelberg.
  3. ^ a b c Bickmore, Wendy Anne (1986). Molecular analysis of DNA sequences from the human Y chromosome (PhD thesis). University of Edinburgh. hdl:1842/10808. EThOS uk.bl.ethos.375478. Free to read
  4. ^ a b Bickmore, Wendy A.; Bird, Adrian P. (1992). Use of restriction endonucleases to detect and isolate genes from mammalian cells. Methods in Enzymology. 216. pp. 224–244. doi:10.1016/0076-6879(92)16024-e. ISBN 9780121821173. PMID 1336093.
  5. ^ a b c d "Bickmore, Prof. Wendy Anne, (Born 28 July 1961), Director, MRC Human Genetics Unit, University of Edinburgh, since 2015". Who's Who. Oxford University Press. 1 December 2016. doi:10.1093/ww/9780199540884.013.u274935. ISBN 978-0-19-954088-4. Retrieved 28 April 2019.
  6. ^ Rose, Steven P. R. (Steven Peter Russell), 1938- (1979). The chemistry of life. Sanderson, Cath (2nd ed.). Harmondsworth: Penguin. ISBN 0-14-020790-2. OCLC 6426479.CS1 maint: multiple names: authors list (link)
  7. ^ Bickmore, Wendy Anne (1986). Molecular analysis of DNA sequences from the human Y chromosome (Thesis).
  8. ^ a b Wendy Bickmore "Wendy Bickmore website". Retrieved 28 November 2021.
  9. ^ "Prof Wendy Bickmore – Packing DNA". thenakedscientists.com.
  10. ^ "wendy bickmore". Archived from the original on 3 April 2009.
  11. ^ Pritchard-Jones, Kathryn; Fleming, Stewart; Davidson, Duncan; Bickmore, Wendy; Porteous, David; Gosden, Christine; Bard, Jonathan; Buckler, Alan; Pelletier, Jerry (1990). "The candidate Wilms' tumour gene is involved in genitourinary development". Nature. 346 (6280): 194–197. Bibcode:1990Natur.346..194P. doi:10.1038/346194a0. PMID 2164159. S2CID 4350729.
  12. ^ Croft, Jenny A.; Bridger, Joanna M.; Boyle, Shelagh; Perry, Paul; Teague, Peter; Bickmore, Wendy A. (1999). "Differences in the Localization and Morphology of Chromosomes in the Human Nucleus". Journal of Cell Biology. 145 (6): 1119–1131. doi:10.1083/jcb.145.6.1119. ISSN 0021-9525. PMC 2133153. PMID 10366586.
  13. ^ Fraser, Peter; Bickmore, Wendy (2007). "Nuclear organization of the genome and the potential for gene regulation". Nature. 447 (7143): 413–417. Bibcode:2007Natur.447..413F. doi:10.1038/nature05916. PMID 17522674. S2CID 4388060.
  14. ^ "New Year Honours: who from Herefordshire has been recognised?". Hereford Times. Retrieved 28 November 2021.
  15. ^ "History". Genetics Society. Retrieved 28 November 2021.
  16. ^ Wendy Bickmore ORCID 0000-0001-6660-7735
  17. ^ "Genes & Development -- Genes & Development Editorial Board". genesdev.cshlp.org. Retrieved 28 April 2019.
  18. ^ "Professor Wendy Bickmore FRS FRSE FMedSci". acmedsci.ac.uk.
  19. ^ Anon (2017). "Wendy Bickmore FRS". London: royalsociety.org.
  20. ^ "No. 63218". The London Gazette (Supplement). 31 December 2020. p. N8.
  21. ^ Wimmer, Doris. "Wendy Bickmore". ESHG Conference 2020. Retrieved 28 November 2021.