Portions of the roadway south of Wayne run along an old Norfolk and Western Railroadbed. There is an abandoned depot at Dunlow. Under some of the highway bridges, you can find shared abutments with the old railroad crossing.
WV 152 was formerly part of U.S. Route 52. The current designation was created in the 1960s, when US 52 was rerouted a few miles to the west in order to facilitate the construction of a more modern highway along the Tug Fork and Big Sandy River. The West Virginia Department of Transportation redesignated the former segment of US 52 as WV 152 in order to demonstrate the road's connection to US 52.