Whetstone may refer to:
- Whetstone, a sharpening stone used for knives and other cutting tools
- Hornfels, known by miners in northern England as whetstone
- Whetstone (surname)
- Whetstone (benchmark), a benchmark for measuring computing power
- Operation Whetstone, a nuclear test program in the 1960s
- Whetstone, a fictional county in the video game Grand Theft Auto: San Andreas
- Whetstone, Leicestershire, a village and civil parish
- Whetstone, London
- Whetstones (stone circle), an ancient pagan monument in Shropshire
- Whetstone, Arizona, a census-designated place
- Whetstone, West Virginia, an unincorporated community
- The Whetstone River in South Dakota and Minnesota
- Whetstone High School (Columbus, Ohio), a high school located in the Clintonville suburb of Columbus, Ohio
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