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1519 – Spanish conquistador Hernán Cortés established a settlement in Mexico, naming it " " ("Rich village of the Villa Rica de la Vera Cruz True Cross").
1529 – Spain and Portugal signed the , defining the areas of their respective influence in Asia.
Treaty of Zaragoza refimprove section
1930 – France, Italy, Japan, the United Kingdom, and the United States signed the , regulating London Naval Treaty submarine warfare and limiting military ship building.
1945 – About 600 prisoners of the in the Jasenovac concentration camp Independent State of Croatia revolted, but only 80 managed to escape while the other 520 were killed by the Croatian Ustashe regime.
unreferenced section, section needs to be rewritten
1969 – The British yachtsman Robin Knox-Johnston won the to complete the first solo non-stop Sunday Times Golden Globe Race circumnavigation of the world.
1993 – The first version of , created by computer programmers Mosaic Marc Andreessen and Eric Bina at the National Center for Supercomputing Applications of the University of Illinois at Urbana–Champaign, was released, becoming the first popular web browser and Gopher client.
1998 – at the Disney's Animal Kingdom Walt Disney World Resort in Florida opened, covering more than 500 acres (2 km 2), making it the largest single Disney theme park in the world.
2000 – In response to the rapid late 1990s growth of telecommunications, the United Kingdom enacted the , modifying the Big Number Change telephone numbering plans in various areas across the country.
2000 – In a predawn raid, U.S. Immigration and Naturalization Service agents seized six-year-old from his relatives' home in Elián González Miami, Florida, and returned him to his Cuban father.
1622 – An Anglo-Persian force combined to the Portuguese garrison at capture Hormuz Island in the Persian Gulf.
1864 – The U.S. Congress passed the Coinage Act, authorizing the minting of a , the first two-cent coin U.S. coin to bear the phrase " ". In God We Trust
1951 – Korean War: The People's Volunteer Army of China attacked positions occupied mainly by Australian and Canadian forces, starting the . Battle of Kapyong
1983 – The West German news magazine published excerpts from what purported to be the Stern , which were subsequently revealed to be forgeries. diaries of Adolf Hitler
2004 – Flammable cargo at exploded Ryongchon Station in Ryongchon, North Korea, killing up to 3,000 people.
2016 – The multinational , dealing with Paris Agreement greenhouse gas emissions mitigation, adaptation, and finance starting in the year 2020, opened for signature. Born/died: (b. 1844) Lewis Powell · (b. 1912) Kathleen Ferrier · (d. 1989) Emilio Segrè
: April 22
The Oklahoma Land Rush of 1889
(b. 1766) Germaine de Staël · (d. 1778) James Hargreaves · (d. 1945)