Wikipedia:WikiProject Medicine/Translation task force/RTT/Simple simvastatin
|Trade names||Zocor, other|
|Elimination half-life||2 hours for simvastatin and 1.9 hours for simvastatin acid|
|Excretion||Renal 13%, faecal 60%|
|Chemical and physical data|
|Molar mass||418.566 g/mol|
|3D model (JSmol)|
Simvastatin, marketed under the trade name Zocor among others, is a lipid lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth.
Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels. Common side effects include constipation, headaches, and nausea. A lower dose may be needed in people with kidney problems. There is evidence of harm to a baby when taken during pregnancy. It should not be used by those who are breastfeeding. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver.
Simvastatin was developed by Merck and came into medical use in 1992. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost is 0.01 to 0.12 USD per day as of 2014. In the United States it costs between 0.50 and 1.00 USD per day. Simvastatin is made from the fungus Aspergillus terreus.
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- "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved May 10, 2015.
- "Simvastatin". International Drug Price Indicator Guide. Retrieved 28 November 2015.