Wikipedia:WikiProject Medicine/Translation task force/RTT/Simple simvastatin

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Simvastatin (INN)
Simvastatin.svg
Simvastatin3Dan.gif
Clinical data
Pronunciation /ˈsɪmvəstætɪn/
Trade names Zocor, other
AHFS/Drugs.com Monograph
MedlinePlus a692030
License data
Pregnancy
category
  • AU: D
  • US: X (Contraindicated)
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 5%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Elimination half-life 2 hours for simvastatin and 1.9 hours for simvastatin acid
Excretion Renal 13%, faecal 60%
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C25H38O5
Molar mass 418.566 g/mol
3D model (JSmol)
  (verify)

Simvastatin, marketed under the trade name Zocor among others, is a lipid lowering medication.[1] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth.[1]

Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels. Common side effects include constipation, headaches, and nausea. A lower dose may be needed in people with kidney problems.[1] There is evidence of harm to a baby when taken during pregnancy.[1][2] It should not be used by those who are breastfeeding. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver.[1]

Simvastatin was developed by Merck and came into medical use in 1992.[3] It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.[4] It is available as a generic medication.[1] The wholesale cost is 0.01 to 0.12 USD per day as of 2014.[5] In the United States it costs between 0.50 and 1.00 USD per day.[1] Simvastatin is made from the fungus Aspergillus terreus.[3]

References[edit]

  1. ^ a b c d e f g "Simvastatin". The American Society of Health-System Pharmacists. Retrieved Jan 8, 2015.
  2. ^ "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.
  3. ^ a b Cechinel-Filho, Valdir (2012). Plant bioactives and drug discovery : principles, practice, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 104. ISBN 9780470582268.
  4. ^ "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved May 10, 2015.
  5. ^ "Simvastatin". International Drug Price Indicator Guide. Retrieved 28 November 2015.