Wilcox is an unincorporated community in Gilchrist County, Florida, United States. It is located about 1 mile (1.6 km) west of Lottieville, at the bend in State Road 26.
Wilcox is located at 29°36′40″N 82°55′19″W / 29.611°N 82.922°W, its elevation 39 feet (12 m).
Wilcox was the westernmost stop on the Atlantic Coast Line Railroad Jacksonville—Wilcox Line, before that line connected to a wye at Wilcox Junction with the Atlantic Coast Line Railroad Thomasville—Dunnellon Line. Today, all three legs of this wye are used by the Nature Coast State Trail.