The video is set in a 1960s ambienced cabaret bar, where a frantic series of unannounced performers lip-synch to the song, imitating such singers as Madonna and Billy Idol. Byrne wrote about this scene:
The song itself becomes a vehicle that can say anything they want it to. Some gestures and movements are obviously derived from well-known sources: television shows ... movies ... and, most recently, rock videos. Odd to think that some lip-synchers are imitating characters in videos, who are really musicians imitating other chatracters.
Actor John Goodman, prior to his fame in the sitcom Roseanne, appeared in both the film and MTV versions of the video. Goodman was also featured on the B-side's "People Like Us", a song which also appeared in the film.