William Acton may refer to:
- William Acton (doctor) (1813–1875), British doctor and writer.
- Sir William Acton, 1st Baronet (died 1651), English merchant and Royalist
- William Acton (politician, died 1744), English MP
- William Acton (politician, died 1567), English MP
- William Acton, warden of the Marshalsea prison, London, in the 1720s
- William Acton (Wicklow MP) (1789–1854), MP for Wicklow 1841–48
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