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His work is predominantly abstract and conceptual. Early works such as Relief (1961) and Issue (1966) incorporate the use of industrial and construction materials. His works are held by the Metropolitan Museum of Art, the Museum of Modern Art, the Guggenheim Museum, the Whitney Museum, the Walker Art Center, the National Gallery of Art, and the Art Institute of Chicago. In 2010 Anastasi was awarded the Foundation for Contemporary Arts John Cage Award, an unrestricted grant awarded biennially.
- "TWO SHOWS THAT SHED LIGHT ON 'ROLYWHOLYOVER' SUPPLEMENTS TO JOHN CAGE'S EXHIBITION". Philadelphia Inquirer. June 9, 1995. pp. 36 FW. Retrieved 29 May 2012.
- Phong Bui, "In Conversation: William Anastasi with Pong Bui" the Brooklyn Rail, July–August 2007.http://brooklynrail.org/2007/07/art/william-anastasi-with-phong-bui
- "William Anastasi | Nine Polaroid Photographs of a Mirror | The Met". The Metropolitan Museum of Art, i.e. The Met Museum. Retrieved 2016-08-25.
- William Anastasi's page on the web site of his dealer, Sandra Gering Inc.
- Print Retrospective Exhibition
- Brooklyn Rail In Conversation William Anastasi with Phong Bui
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