||This article needs attention from an expert in chemistry. (March 2011)|
|William N. Lipscomb, Jr.|
December 9, 1919|
Cleveland, Ohio, US
|Died||April 14, 2011
Cambridge, Massachusetts, US
|Fields||Nuclear magnetic resonance
|Institutions||University of Minnesota
|Alma mater||University of Kentucky
California Institute of Technology
|Doctoral advisor||Linus Pauling|
|Doctoral students||Richard E. Dickerson
Russell M. Pitzer
Thomas A. Steitz
Don C. Wiley
David A. Dixon
|Other notable students||Martha L. Ludwig
Raymond C. Stevens
|Notable awards||Nobel Prize in Chemistry (1976)|
William Nunn Lipscomb, Jr. (December 9, 1919 – April 14, 2011) was a Nobel Prize-winning American inorganic and organic chemist working in nuclear magnetic resonance, theoretical chemistry, boron chemistry, and biochemistry.
- 1 Biography
- 2 Scientific studies
- 3 Positions, awards and honors
- 4 References
- 5 External links
Lipscomb was born in Cleveland, Ohio. His family moved to Lexington, Kentucky in 1920, and he lived there until he received his Bachelor of Science degree in Chemistry at the University of Kentucky in 1941. He went on to earn his Doctor of Philosophy degree in Chemistry from the California Institute of Technology (Caltech) in 1946.
Lipscomb was married to the former Mary Adele Sargent from 1944 to 1983. They had three children, one of whom lived only a few hours. He married Jean Evans in 1983. They had one adopted daughter.
"My early home environment ... stressed personal responsibility and self reliance. Independence was encouraged especially in the early years when my mother taught music and when my father's medical practice occupied most of his time."
In grade school Lipscomb collected animals, insects, pets, rocks, and minerals.
Interest in astronomy led him to visitor nights at the Observatory of the University of Kentucky, where Prof. H. H. Downing gave him a copy of Baker's Astronomy. Lipscomb credits gaining many intuitive physics concepts from this book and from his conversations with Downing, who became Lipscomb's lifelong friend.
At age of 12, Lipscomb was given a small Gilbert chemistry set, He expanded it by ordering apparatus and chemicals from suppliers and by using his father's privilege as a physician to purchase chemicals at the local drugstore at a discount. Lipscomb made his own fireworks and entertained visitors with color changes, odors, and explosions. His mother questioned his home chemistry hobby only once, when he attempted to isolate a large amount of urea from urine.
Lipscomb credits perusing the large medical texts in his physician father's library and the influence of Linus Pauling years later to his undertaking biochemical studies in his later years. Had Lipscomb become a physician like his father, he would have been the fourth physician in a row along the Lipscomb male line.
The source for this subsection, except as noted, is Lipscomb's autobiographical sketch.
Lipscomb's high-school chemistry teacher, Frederick Jones, gave Lipscomb his college books on organic, analytical, and general chemistry, and asked only that Lipscomb take the examinations. During the class lectures, Lipscomb in the back of the classroom did research that he thought was original (but he later found was not): the preparation of hydrogen from sodium formate (or sodium oxalate) and sodium hydroxide. He took care to include gas analyses and to search for probable side reactions.
Lipscomb later had a high-school physics course and took first prize in the state contest on that subject. He also became very interested in special relativity.
In college at the University of Kentucky Lipscomb had a music scholarship. He pursued independent study there, reading Dushman' s Elements of Quantum Mechanics, the University of Pittsburgh Physics Staff's An Outline of Atomic Physics, and Pauling's The Nature of the Chemical Bond and the Structure of Molecules and Crystals. Prof. Robert H. Baker suggested that Lipscomb research the direct preparation of derivatives of alcohols from dilute aqueous solution without first separating the alcohol and water, which led to Lipscomb's first publication.
For graduate school Lipscomb chose Caltech, which offered him a teaching assistantship in Physics at $20/month. He turned down more money from Northwestern University, which offered a research assistantship at $150/month. Columbia University rejected Lipscomb's application in a letter written by Nobel prizewinner Prof. Harold Urey.
At Caltech Lipscomb intended to study theoretical quantum mechanics with Prof. W. V. Houston in the Physics Department, but after one semester switched to the Chemistry Department under the influence of Prof. Linus Pauling. World War II work divided Lipscomb's time in graduate school beyond his other thesis work, as he partly analyzed smoke particle size, but mostly worked with nitroglycerin-nitrocellulose propellants, which involved handling vials of pure nitroglycerin on many occasions. Brief audio clips by Lipscomb about his war work may be found from the External Links section at the bottom of this page, past the References.
The source for this subsection, except as noted, is Lipscomb's autobiographical sketch.
The Colonel is how Lipscomb's students referred to him, directly addressing him as Colonel. "His first doctoral student, Murray Vernon King, pinned the label on him, and it was quickly adopted by other students, who wanted to use an appellation that showed informal respect. ... Lipscomb's Kentucky origins as the rationale for the designation." Some years later in 1973 Lipscomb was made a member of the Honorable Order of Kentucky Colonels.
Lipscomb has worked in three main areas, nuclear magnetic resonance and the chemical shift, boron chemistry and the nature of the chemical bond, and large biochemical molecules. These areas overlap in time and share some scientific techniques. In at least the first two of these areas Lipscomb gave himself a big challenge likely to fail, and then plotted a course of intermediate goals.
Nuclear magnetic resonance and the chemical shift
In this area Lipscomb proposed that: "... progress in structure determination, for new polyborane species and for substituted boranes and carboranes, would be greatly accelerated if the [boron-11] nuclear magnetic resonance spectra, rather than X-ray diffraction, could be used." This goal was partially achieved, although X-ray diffraction is still necessary to determine many such atomic structures. The diagram at left shows a typical nuclear magnetic resonance (NMR) spectrum of a borane molecule.
Lipscomb investigated, "... the carboranes, C2B10H12, and the sites of electrophilic attack on these compounds using nuclear magnetic resonance (NMR) spectroscopy. This work led to [Lipscomb's publication of a comprehensive] theory of chemical shifts. The calculations provided the first accurate values for the constants that describe the behavior of several types of molecules in magnetic or electric fields."
Much of this work is summarized in a book by Gareth Eaton and William Lipscomb, NMR Studies of Boron Hydrides and Related Compounds, one of Lipscomb's two books.
Boron chemistry and the nature of the chemical bond
In this area Lipscomb originally intended a more ambitious project: "My original intention in the late 1940s was to spend a few years understanding the boranes, and then to discover a systematic valence description of the vast numbers of electron deficient intermetallic compounds. I have made little progress toward this latter objective. Instead, the field of boron chemistry has grown enormously, and a systematic understanding of some of its complexities has now begun." Examples of these intermetallic compounds are KHg13 and Cu5Zn7. Of perhaps 24,000 of such compounds the structures of only 4,000 are known (in 2005) and we cannot predict structures for the others, because we do not sufficiently understand the nature of the chemical bond. This study was not successful, in part because the calculation time required for intermetallic compounds was out of reach in the 1960s, but intermediate goals involving boron bonding were achieved, sufficient to be awarded a Nobel Prize.
Lipscomb deduced the molecular structure of boranes (compounds of boron and hydrogen) using X-ray crystallography in the 1950s and developed theories to explain their bonds. Later he applied the same methods to related problems, including the structure of carboranes (compounds of carbon, boron, and hydrogen).
The three-center two-electron bond is illustrated in diborane (diagrams at right). In an ordinary covalent bond a pair of electrons bonds two atoms together, one at either end of the bond, the diboare B-H bonds for example at the left and right in the illustrations. In three-center two-electron bond a pair of electrons bonds three atoms (a boron atom at either end and a hydrogen atom in the middle), the diborane B-H-B bonds for example at the top and bottom of the illustrations.
Lipscomb's group did not propose or discover the three-center two-electron bond, nor did they develop formulas that give the proposed mechanism. What they did was to use formulas written by others intended for another purpose to understand the quantum mechanicical details of the three-center two-electron bond.
A trail of credit for the understanding the three-center two-electron bond follows: Over several decades the structure and bonding arrangement of diborane was gradually discovered by Dilthey, Price, and others. Longuet-Higgins and Roberts employed a three-center two-electron bond as the correct way to understand bonding in diborane using a molecular orbital description similar to what the Lipscomb group found. Eberhardt, Crawford, and Lipscomb proposed the mechanism of the three-center two-electron bond, and Lipscomb's group achieved an understanding of it through electron orbital calculations using formulas by Edmiston and Ruedenberg and by Boys.
The Eberhardt, Crawford, and Lipscomb paper discussed above also devised the "styx number" method to catalog certain kinds of boron-hydride bonding configurations.
Wandering atoms was a puzzle solved by Lipscomb in one of his few papers with no co-authors. Compounds of boron and hydrogen tend to form closed cage structures. Sometimes the atoms at the vertices of these cages move substantial distances with respect to each other. The diamond-square-diamond mechanism (diagram at left) was suggested by Lipscomb to explain this rearrangement of vertices. Following along in the diagram at left for example in the faces shaded in blue, a pair of triangular faces has a left-right diamond shape. First, the bond common to these adjacent triangles breaks, forming a square, and then the square collapses back to an up-down diamond shape by bonding the atoms that were not bonded before. Other researchers have discovered more about these rearrangements. 
The B10H16 structure (diagram at right) determined by Grimes, Wang, Lewin, and Lipscomb found a bond directly between two boron atoms without terminal hydrogens, a feature not previously seen in other boron hydrides.
Lipscomb's group developed calculation methods, both empirical and from quantum mechanical theory. Calculations by these methods produced accurate Hartree–Fock self-consistent field (SCF) molecular orbitals and were used to study boranes and carboranes.
Lipscomb's calculations continued to a detailed examination of partial bonding through "... theoretical studies of multicentered chemical bonds including both delocalized and localized molecular orbitals." This included "... proposed molecular orbital descriptions in which the bonding electrons are delocalized over the whole molecule."
"Lipscomb and his coworkers developed the idea of transferability of atomic properties, by which approximate theories for complex molecules are developed from more exact calculations for simpler but chemically related molecules,..."
Subsequent Nobel Prize winner Roald Hoffmann was a doctoral student      in Lipscomb's laboratory. Under Lipscomb's direction the Extended Huckel method of molecular orbital calculation was developed by Lawrence Lohr and by Roald Hoffmann. This method was later extended by Hoffman. In Lipscomb's laboratory this method was reconciled with self-consistent field (SCF) theory by Newton and by Boer.
Much of this work is summarized in a book by Lipscomb, Boron Hydrides, one of Lipscomb's two books.
The 1976 Nobel Prize in Chemistry was awarded to Lipscomb "for his studies on the structure of boranes illuminating problems of chemical bonding". In a way this continued work on the nature of the chemical bond by his Doctoral Advisor at the California Institute of Technology, Linus Pauling, who was awarded the 1954 Nobel Prize in Chemistry "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances."
Large biological molecule structure and function
Lipscomb's later research focused on the atomic structure of proteins, particularly how enzymes work. His group used x-ray diffraction to solve the three-dimensional structure of these proteins to atomic resolution, and then to analyze the atomic detail of how the molecules work.
The images below are of Lipscomb's structures from the Protein Data Bank displayed in simplified form with atomic detail suppressed. Proteins are chains of amino acids, and the continuous ribbon shows the trace of the chain with, for example, several amino acids for each turn of a helix.
Carboxypeptidase A (left) was the first protein structure from Lipscomb's group. Carboxypeptidase A is a digestive enzyme, a protein that digests other proteins. It is made in the pancreas and transported in inactive form to the intestines where it is activated. Carboxypeptidase A digests by chopping off certain amino acids one-by-one from one end of a protein. The size of this structure was ambitious. Carboxypeptidase A was a much larger molecule than anything solved previously.
Aspartate carbamoyltransferase. (right) was the second protein structure from Lipscomb's group. For a copy of DNA to be made, a duplicate set of its nucleotides is required. Aspartate carbamoyltransferase performs a step in building the pyrimidine nucleotides (cytosine and thymidine). Aspartate carbamoyltransferase also ensures that just the right amount of pyrimidine nucleotides is available, as activator and inhibitor molecules attach to aspartate carbamoyltransferase to speed it up and to slow it down. Aspartate carbamoyltransferase is a complex of twelve molecules. Six large catalytic molecules in the interior do the work, and six small regulatory molecules on the outside control how fast the catalytic units work. The size of this structure was ambitious. Aspartate carbamoyltransferase was a much larger molecule than anything solved previously.
Fructose-1,6-bisphosphatase (left) and its inhibitor MB06322 (CS-917) were studied by Lipscomb's group in a collaboration, which included Metabasis Therapeutics, Inc., acquired by Ligand Pharmaceuticals in 2010, exploring the possibility of finding a treatment for type 2 diabetes, as the MB06322 inhibitor slows the production of sugar by fructose-1,6-bisphosphatase.
Subsequent Nobel Prize winner Thomas A. Steitz was a doctoral student in Lipscomb's laboratory. Under Lipscomb's direction, after the training task of determining the structure of the small molecule methyl ethylene phosphate, Steitz made contributions to determining the atomic structures of carboxypeptidase A         and aspartate carbamoyltransferase.  Steitz was awarded the 2009 Nobel Prize in Chemistry for determining the even larger structure of the large 50S ribosomal subunit, leading to an understanding of possible medical treatments.
Subsequent Nobel Prize winner Ada Yonath, who shared the 2009 Nobel Prize in Chemistry with Thomas A. Steitz and Venkatraman Ramakrishnan, spent some time in Lipscomb's lab where both she and Steitz were inspired to pursue later their own very large structures. This was while she was a postdoctoral student at MIT in 1970.
The mineral lipscombite (picture at right) was named after Professor Lipscomb by the mineralogist John Gruner who first made it artificially.
Low-temperature x-ray diffraction was pioneered in Lipscomb's laboratory at about the same time as parallel work in Isadore Fankuchen's laboratory at the then Polytechnic Institute of Brooklyn. Lipscomb began by studying compounds of nitrogen, oxygen, fluorine, and other substances that are solid only below liquid nitrogen temperatures, but other advantages eventually made low-temperatures a normal procedure. Keeping the crystal cold during data collection produces a less-blurry 3-D electron-density map because the atoms have less thermal motion. Crystals may yield good data in the x-ray beam longer because x-ray damage may be reduced during data collection and because the solvent may evaporate more slowly, which for example may be important for large biochemical molecules whose crystals often have a high percentage of water.
Other important compounds were studied by Lipscomb and his students. Among these are hydrazine, nitric oxide, metal-dithiolene complexes, methyl ethylene phosphate, mercury amides, (NO)2, crystalline hydrogen fluoride, Roussin's black salt, (PCF3)5, complexes of cyclo-octatetraene with iron tricarbonyl, and leurocristine (Vincristine), which is used in several cancer therapies.
Positions, awards and honors
- Guggenheim Fellow, 1954
- Fellow of the American Academy of Arts and Sciences in 1960.
- Member of United States National Academy of Sciences
- Member of the Faculty Advisory Board of MIT-Harvard Research Journal
- Foreign Member of the Royal Netherlands Academy of Arts and Sciences, (1976)
- Nobel Prize in Chemistry, (1976)
A complete list of Lipscomb's awards and honors is in his Curriculum Vitae.
- "William Lipscomb - Autobiography". Nobelprize.org. Retrieved 2012-02-01.
- Rifkin, Glenn (2011-04-15). "William Lipscomb, Nobel Winner in Chemistry, Dies at 91". The New York Times.
- LorraineGilmer02 (View posts) (2007-09-27). "obit fyi - Mary Adele SARGENT Lipscomb, 1923 Ca. - 2007 NC - Sargent - Family History & Genealogy Message Board - Ancestry.com". Boards.ancestry.com. Retrieved 2012-02-01.
- Maugh II, Thomas H. (2011-04-16). "OBITUARY: William N. Lipscomb dies at 91; won Nobel Prize in chemistry - Los Angeles Times". Articles.latimes.com. Retrieved 2012-02-01.
- Kauffman, George B.; Jean-Pierre Adloff (19 July 2011). "William Nunn Lipscomb, Jr. (1919–2011), Nobel Laureate and Borane Chemistry Pioneer: An Obituary-Tribute". The Chemical Educator 16: 195–201. Retrieved 16 August 2011.
- Structures and Mechanisms: From Ashes to Enzymes (Acs Symposium Series) Gareth R. Eaton (Editor), Don C. Wiley (Editor), Oleg Jardetzky (Editor), .American Chemical Society, Washington, DC, 2002 ("Process of Discovery (1977); An Autobiographical Sketch" by William Lipscomb, 14 pp. (Lipscombite: p. xvii), and Chapter 1: "The Landscape and the Horizon. An Introduction to the Science of William N. Lipscomb", by Gareth Eaton, 16 pp.) These chapters are online at pubs.acs.org. Click PDF symbols at right.
- "HighSchool - Publications - Lipscomb". Wlipscomb.tripod.com. 1937-02-25. Retrieved 2012-02-01.
- Lipscomb, W. N. and Baker, R. H., The Identification of Alcohols in Aqueous Solution, J. Am. Chem. Soc. 64, 179 (1942).
- Katz, Lewis. Letter presented to Bill on the occasion of his 80th birthday, collected with others in a Festschrift (party book), May 12–14, 2000.
- Hargittai, Istvan (2003). Candid Science III: More Conversations with Famous Chemists. London, UK: Imperial College Press. p. 27.
- Lipscomb WN. The Boranes and Their Relatives. Science: 196(4294):1047-1055 (3 June 1977).
- Potenza, J. A., Lipscomb, W. N., Vickers, G. D., and Schroeder, H., "Order of Electrophilic Substitution in 1,2 Dicarbaclovododecaborane(12) and Nuclear Magnetic Resonance Assignment," J. Am. Chem. Soc. 88, 628 (1966).
- Lipscomb WN, The chemical shift and other second-order magnetic and electric properties of small molecules. Advances in Nuclear Magnetic Resonance. Edited by J. Waugh, Vol. 2 (Academic Press, 1966), pp. 137-176
- Hutchinson Dictionary of Scientific Biography, Lipscomb, William Nunn (1919-) (5 paragraphs) © RM, 2011, all rights reserved, as published under license in AccessScience, The McGraw-Hill Encyclopedia of Science & Technology Online, © The McGraw-Hill Companies, 2000-2008. Helicon Publishing is a division of RM. To see this biography (1) Go to accessscience.com (2) Search for Lipscomb (3) at right Click on "Lipscomb, William Nunn (1919- ). (4) If no institutional access is available, then at right click on Purchase Now (price in 2011 is about $30 US including tax for 24 hours). (5) Log in (6) Repeat steps 2 and 3.to see Lipscomb's biography.
- Eaton GR, Lipscomb, WN. 1969. NMR Studies of Boron Hydrides and Related Compounds. W. A. Benjamin, Inc.
- Lipscomb WN. 1977. The Boranes and Their Relatives. in Les Prix Nobel en 1976. Imprimerie Royal PA Norstedt & Soner, Stockholm. 110-131. Quote in next to last paragraph, which is omitted in Science version of the paper.
- Eberhardt, W. H., Crawford, B., and Lipscomb, W. N., "The Valence Structure of the Boron Hydrides," J. Chem. Phys. 22, 989 (1954).
- Dilthey, W., Uber die Konstitution des Wassers, Z. Agnew. Chem., 34, 596 (1921)
- Price, W.C., The structure of diborane, J. Chem. Phys., 15, 614 (1947)
- Price, W.C., The absorption spectrum of diborane, J. Chem. Phys., 16, 894 (1948)
- Longuet-Higgins HC. Roberts M de V., Proc. Royal Soc. (London) A234, 336 (1954).
- Longuet-Higgins HC. Roberts M de V., The Electronic Structure of an Icosahedron of Boron Atoms. Proc. Royal Soc. (London) A230, 110-l19 (1955).
- Kleier, D. A., Hall, J. H. Jr., Halgren, T. A., & Lipscomb, W. N., "Localized Molecular Orbitals for Polyatomic Molecules. I. A Comparison of the Edmiston-Ruedenberg and the Boys Localization Methods," J Chem. Phys. 61, 3905 (1974).
- Lipscomb, W. N., Framework Rearrangement in Boranes and Carboranes, Science 153, 373 (1966).
- Hutton, Brian W.; MacIntosh, Fraser, Ellis, David, Herisse, Fabien, Macgregor, Stuart A., McKay, David, Petrie-Armstrong, Victoria, Rosair, Georgina M., Perekalin, Dmitry S., Tricas, Hugo, Welch, Alan J. (31 December 2007). "Unprecedented steric deformation of ortho-carborane". Chemical Communications (42): 5345–5347. doi:10.1039/B810702E.
- Hosmane, N.S., Zhang, H., Maguire, J.A., Wang, Y., Colacot, T.J., & Gray, T.G., The First Carborane with a Distorted Cuboctahedral Structure, Angew. Chem., Int. Ed. Engl. 1996, 35, 1000-1002.
- Grimes, R., Wang, F. E., Lewin, R., and Lipscomb, W. N., A New Type of Boron Hydride, B10H16, Proc. Natl. Acad. Sci. USA 47, 996-999 (1961).
- Pitzer, R. M., Kern, C. W. and Lipscomb, W. N., "Evaluation of Molecular Integrals by Solid Spherical Harmonic Expansions," J Chem. Phys. 37, 267 (1962).
- Stevens, RM, Pitzer RM, Lipscomb WN. Perturbed Hartree-Fock Calculations. I. Magnetic Susceptibility and Shielding in the LiH Molecule. J. Chem. Phys. 38, 550-560 (1963).
- Pitzer RM and Lipscomb WN, "Calculation of the Barrier to Internal Rotation in Ethane", Chem. Phys., 39, 1995-2004 (1963)
- Hoffmann R and Lipscomb WN, Theory of Polyhedral Molecules. III. Population Analyses and Reactivities for the Carboranes, J. Chem. Phys., 36, 3489 (1962).
- Hoffmann R and Lipscomb WN, Theory of Polyhedral Molecules. I. Physical Factorizations of the Secular Equation, J. Chem. Phys., 36, 2179 (1962).
- Hoffmann R and Lipscomb WN, The Boron Hydrides; LCAO-MO and Resonance Studies, J.Chem. Phys., 37, 2872 (1962).
- Hoffmann R and Lipscomb WN, Sequential Substitution Reactions on B10H10-2 and B12H12-2, J. Chem. Phys., 37, 520 (1962).
- Hoffmann R and Lipscomb WN, Intramolecular Isomerization and Transformations in Carboranes and Substituted Boron Hydrides, Inor. Chem., 2, 231 (1963).
- Lipscomb WN. Boron Hydrides, W. A. Benjamin Inc., New York, 1963 (Calculation methods are in Chapter 3).
- Hoffmann R. An Extended Hückel Theory. I. Hydrocarbons. J. Chem. Phys, 39, 1397-1412 (1963).
- Newton MD, Boer FP, Lipscomb WN. Molecular Orbital Theory for Large Molecules. Approximation of the SCF LCAO Hamiltonian Matrix." J. Am. Chem. Soc. 88, 2353-2360 245 (1966).
- Boer FP, Newton MD, Lipscomb WN. Molecular Orbitals for Boron Hydrides Parameterized from SCF Model Calculations." J. Am. Chem. Soc. 88, 2361-2366 (1966).
- Lipscomb, W. N., Pitochelli, A. R. and Hawthorne, M. F., "Probable Structure of the B10H10-2 Ion," J Am. Chem. Sc. 81, 5833 (1959).
- Pitochelli, A. R., Lipscomb, W. N. and Hawthorne, M. F., "Isomers of B20H18-2," J Am. Chem. Soc. 84, 3026 (1962).
- Lipscomb, W. N., Wiersma, R. J. and Hawthorne, M. F., "Structural Ambiguity of the B10H14-2 Ion," Inorg. Chem. 11, 651 (1972).
- Paxson, T. E., Hawthorne, M. F., Brown, L. D., & Lipscomb, W. N., "Observations Regarding Cu-H-B Interactions in Cu2B10H10," Inorg. Chem. 13, 2772 (1974).
- "The Nobel Prize in Chemistry 1976". Nobelprize.org. Retrieved 2012-02-01.
- "The Nobel Prize in Chemistry 1954". Nobelprize.org. Retrieved 2012-02-01.
- "rcsb.org". rcsb.org. Retrieved 2012-02-01.
- Lipscomb WN, Hartsuck JA, Reeke GN, Jr, Quiocho FA, Bethge PH, Ludwig ML, Steitz TA, Muirhead H, Coppola JC. The structure of carboxypeptidase A. VII. The 2.0-angstrom resolution studies of the enzyme and of its complex with glycyltyrosine, and mechanistic deductions. Brookhaven Symp Biol. 1968 Jun;21(1):24–90.
- Honzatko, R. B., Crawford, J. L., Monaco, H. L., Ladner, J. E., Edwards, B. F. P., Evans, D. R., Warren, S. G., Wiley, D. C., Ladner, R. C., & Lipscomb, W. N., "Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli," J Mol. Biol. 160, 219-263 (1983).
- Burley, S. K., David, P. R., Sweet, R. M., Taylor, A., & Lipscomb, W. N., "Structure Determination and Refinement of Bovine Lens Leucine Aminopeptidase and its Complex with Bestatin," J Mol. Biol. 224, 113-140 (1992).
- Reinisch, K. M., Chen, L., Verdine, G. L., and Lipscomb, W. N., The crystal structure of the Hae III methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing, Cell 82, 143-153 (1995).
- Karpusas, M., Nolte, M., Benton, C. B., Meier, W., and Lipscomb, W. N., The crystal structure of human interferon beta at 2.2-A resolution, Proc. Natl. Acad. Sci. USA 94, 11813-11818 (1997).
- Strater, N., Schnappauf G., Braus, G. and Lipscomb, W.N., Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures, Structure 5, 1437-1452 (1997).
- Ke, H., Thorpe, C. M., Seaton, B. A., Lipscomb, W. N., & Marcus, F., "Structure Refinement of Fructose-1,6-bisphosphatase and its Fructose-2,6-bisphosphate Complex at 2.8 A Resolution," J Mol. Biol. 212, 513-539 (1989).
- Erion MD, van Poelje PD, Dang Q, Kasibhatla SR, Potter SC, Reddy MR, Reddy KR, Jiang T, Lipscomb WN. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5 (PubMed)
- "ligand.com". ligand.com. Retrieved 2012-02-01.
- Quiocho, F. A., Reeke, G. N., Becker, J. W., Lipscomb, W. N. and Edelman, G. M., "Structure of Concanavalin A at 4 A Resolution," Proc. Natl. Acad. Sci. USA 68, 1853-1857 (1971).
- Haugen, W. P. and Lipscomb, W. N., "The Crystal and Molecular Structure of the Hormone Glucagon," Acta Cryst. A25, S185 (1969).
- Liang, J .-Y ., & Lipscomb, W. N., "Substrate and Inhibitor Binding to Human Carbonic Anhydrase II: a Theoretical Study," International Workshop on Carbonic Anhydrase (Spoleto, Italy VCH Verlagsgesellschaft, 1991) pp. 50-64.
- Steitz, T. A. and Lipscomb, W. N., "Molecular Structure of Methyl Ethylene Phosphate," J Am. Chem. Soc. 87, 2488 (1965).
- Hartsuck JA, Ludwig ML, Muirhead H, Steitz TA, Lipscomb WN. Carbyxypeptidase A, II, The Three-dimensional Electron Density Map at 6 A Resolution. Proc Natl Acad Sci U S A. 1965 February; 53(2): 396–403.
- Lipscomb, W. N., Coppola, J. C., Hartsuck, J. A., Ludwig, M. L., Muirhead, H., Searl, J. and Steitz, T. A., "The Structure of Carboxypeptidase A. III. Molecular Structure at 6 A Resolution," J Mol. Biol. 19, 423-441 (1966).
- Ludwig, M. L., Coppola, J. C., Hartsuck, J. A., Muirhead, H., Searl, J., Steitz, T. A. and Lipscomb, W. N., "Molecular Structure of Carboxypeptidase A at 6 A Resolution," Federation Proc. 25, Part I, 346 (1966).
- Ludwig ML, Hartsuck JA, Steitz TA, Muirhead H, Coppola JC, Reeke GN, Lipscomb WN. The Structure of Carboxypeptidase A, IV. Prelimitary Results at 2.8 A Resolution, and a Substrate Complex at 6 A Resolution. Proc Natl Acad Sci U S A. 1967 March; 57(3): 511–514.
- Reeke GN, Hartsuck JA, Ludwig ML, Quiocho FA, Steitz TA, Lipscomb WN. The structure of carboxypeptidase A. VI. Some Results at 2.0-A Resolution, and the Complex with Glycyl-Tyrosine at 2.8-A Resolution. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2220–2226.
- Lipscomb, W. N, Ludwig, M. L., Hartsuck, J. A., Steitz, T. A., Muirhead, H., Coppola, J. C., Reeke, G. N. and Quiocho, F. A., "Molecular Structure of Carboxypeptidase A at 2.8 A Resolution and an Isomorphous Enzyme-Substrate Complex at 6 A Resolution," Federation Proc. 26, 385 (1967).
- Coppola, J. C., Hartsuck, J. A., Ludwig, M. L., Muirhead, H., Searl, J., Steitz, T. A. and Lipscomb, W. N., "The Low Resolution Structure of Carboxypeptidase A," Acta Cryst. 21, A160 (1966).
- Steitz TA, Wiley DC, Lipscomb WN. The structure of aspartate transcarbamylase, I. A molecular twofold axis in the complex with cytidine triphosphate. Proc Natl Acad Sci U S A. 1967 November; 58(5): 1859–1861.
- Yarnell, A. Lipscomb Feted in Honor of his 90th Birthday. Chemical and Engineering News, 87, 48, Am. Chem. Soc., p. 35, Nov. 30, 2009.
- Abrahams SC, Collin RL, Lipscomb WN, Reed TB. "Further Techniques in Single-Crystal X-ray Diffraction Studies at Low Temperatures." Rev. Sci. Instr. 21, 396-397 (1950).
- King, M. V. and Lipscomb, W. N., "The Low Temperature Modification of n-Propylammonium Chloride," Acta Cryst. 3, 227 (1950).
- Milberg, M. E. and Lipscomb, W. N., "The Crystal Structure of 1,2-Dichloroethane at -50°C," Acta Cryst. 4, 369 (1951).
- Kaufman HS, Fankuchen I. A Low Temperature Single Crystal X-ray Diffraction Technique. Rev. Sci. Instr. 20, 733-734 (1949).
- Collin, R. L. and Lipscomb, W. N., "The Crystal Structure of Hydrazine," Acta Cryst. 4, 10 (1951).
- Dulmage, W. J., Meyers, E. A., and Lipscomb, W. N., "The Molecular and Crystal Structure of Nitric Oxide Dimer," J. Chem. Phys. 19, 1432 (1951).
- Enemark, J. H. and Lipscomb, W. N., "Molecular Structure of the Dimer of Bis(cis-1,2-bis(trifluoromethyl)-ethylene-1,2-dithiolate)cobalt, " Inorg. Chem. 4, 1729 (1965).
- Lipscomb, W. N., "Recent Studies in the Structural Inorganic Chemistry of Mercury," Mercury and Its Compounds. Annals of the New York Academy of Sciences 65, Art. 5, 427 (1957).
- Lipscomb, W. N., "Structure of (NO)2 in the Molecular Crystal," J. Chem. Phys. 54, 3659-3660 (1971).
- Atoji, M. and Lipscomb, W. N., "The Crystal Structure of Hydrogen Fluoride," Acta Cryst. 7, 173 (1954).
- Johansson, G. and Lipscomb, W. N., "The Structure of Roussin's Black Salt, CsFe4S3(NO)7.H2O," Acta Cryst. 11, 594 (1958).
- Spencer, C. J. and Lipscomb, W, N., "The Molecular and Crystal Structure of (PCF3)5," Acta Cryst. 14, 250 (1961).
- Dickens, B. and Lipscomb, W. N., "Molecular and Valence Structures of Complexes of Cyclo-Octatetraene with Iron Tricarbonyl," J. Chem. Phys. 37, 2084-2093 (1962).
- Moncrief, J. W. and Lipscomb, W. N., "Structures of Leurocristine (Vincristine) and Vincaleukoblastine. X-ray Analysis of Leurocristine Methiodide," J. Am. Chem. Soc. 87, 4963 (1965).
- "All Fellows: L". John Simon Guggenheim Memorial Foundation. Retrieved 15 April 2011.
- "Book of Members, 1780-2010: Chapter L". American Academy of Arts and Sciences. Retrieved 15 April 2011.
- "W.N. Lipscomb". Koninklijke Nederlandse Akademie van Wetenschappen. Retrieved 15 April 2011.(Dutch)
- The Selected Papers of William N Lipscomb Jr.: A Legacy in Structure-Function Relationships. Jainpeng Ma (Editor), Imperial College Press. 400 pp. approx. Winter 2012. (I. C. Press) (Amazon)
- Boron Science: New Technologies and Applications. Narayan Hosmane (Editor), CRC Press, 878 pp. Sept, 26, 2011. (CRC Press) (Amazon)
- Proceedings of the International Symposium on Quantum Chemistry, Solid-State Theory and Molecular Dynamics, International Journal of Quantum Chemistry, Quantum Chemistry Symposium No. 25, St. Augustine, FL, March 9–16 (1991). Ed. P.O. Lowdin, Special Eds. N.Y. Orhn, J.R. Sabin, and M.C. Zemer. Published by John Wiley and Sons. 1991.
- Electron Deficient Boron and Carbon Clusters, Eds: G.A. Olah, K. Wade, and R.E. Williams. An outgrowth of the Jan. 1989 research symposium at the Loker Hydrocarbon Research Institute on Electron Deficient Clusters. Wiley – Interscience, New York, 1989. (Dedication to "The Colonel" by F. Albert Cotton, 3 pp.)
- "CV - Biog - Publications - Lipscomb". Wlipscomb.tripod.com. Retrieved 2012-02-01.
- Research page at Harvard.
- "Reflections" on Linus Pauling: Video of a talk by Lipscomb. See especially the "Linus and Me" section.
- World War 2 research in brief audio clips by Lipscomb, which include his attempt to save the life of Elizabeth Swingle. Technical description of the Swingle accident.
- Scientific Character of W. Lipscomb Curriculum Vitae, publication list, science humor, Nobel Prize scrapbook, scientific aggression, family stories, portraits, eulogy.