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William Mayo is the name of:
- William B. Mayo (1866-1944), former chief engineer of the Ford Motor Company
- Two co-founders of the Mayo Clinic:
- William Mayo (MP) (died 1723), English Member of Parliament
- William Mayo (civil engineer) (c.1685-1744), who laid out the city of Richmond, Virginia
- William Mayo (vicar), the vicar of Folke, Dorset, England in about 1845.
- William Leonidas Mayo, founder (in 1889) and first president of East Texas Normal College.
- William Starbuck Mayo, (1812-1895), American doctor, traveler and writer
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