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Sir William Withers (1657 – 31 January 1720) was Lord Mayor of London from 1707 to 1708.
He was born in 1657, a descendant of Sir Thomas Wyther. Sir William Withers' father was believed to be the first family member to spell the name Wyther as Withers.
Withers was knighted by William III on 20 October 1699. He was a member of the Worshipful Company of Fishmongers and became Sheriff of London for 1701 and Lord Mayor of London for 1707. He also represented London in the Parliament of England (1700–1701), where he was challenged by his Whig opponent, Sir John Bukworth, for Lord Mayor. Sir William won by a majority of 253 and filled the vacancy in the aftermath of the death of Sir Robert Clayton. He was continually successful in the next elections (1708–1710, 1713) but was thrown out due to the return to power by the Whigs in 1715.
He died on 31 January 1720 and is buried at All Saints Church, Fulham, London.