A 6'6" forward, Murrell played at Kansas State University from 1962 to 1964. He averaged 20.6 points and 10.7 rebounds per game during his time at Kansas State and was a 1964 First Team All-American. In 1964, he led Kansas State to the Final Four of the NCAA Tournament. The team was eliminated by UCLA, despite a 29 point, 13 rebound effort from Murrell.
After college, Murrell played three seasons in the American Basketball Association as a member of the Denver Rockets, Miami Floridians, and Kentucky Colonels. He averaged 13.1 points and 7.3 rebounds in 228 ABA games.
In 2009, Murrell's #44 jersey was retired by Kansas State.