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Wim E. Crusio (born Wilhelmus Elisabeth Crusio on December 20, 1954 in Bergen op Zoom, The Netherlands) is a Dutch behavioral neurogeneticist and a directeur de recherche (research director) with the French National Centre for Scientific Research in Talence, France.
Education and career
Crusio received his bachelor's degree in biology from Radboud University Nijmegen in 1975, where he went on to obtain a master's degree and then a Ph.D. in 1979 and 1984, respectively. His Anubias revision, which was originally published in 1979, was translated in German and continues to engender interest. For his PhD thesis, Crusio studied the inheritance of the effects of anosmia on exploratory behavior of mice, and more in general the genetic architecture of exploratory behavior, using quantitative-genetic methods such as the diallel cross. From 1984 to 1987, Crusio worked as a postdoc at the University of Heidelberg, supported by a NATO Science Fellowship and an Alexander von Humboldt Research Fellowship. During 1988, Crusio spent a year in Paris, France, supported by a fellowship from the Fyssen Foundation. He then returned to Heidelberg as a senior research scientist before being recruited as chargé de recherche by the CNRS, initially working in an institute of the Université René Descartes (Paris V) and later moving to the CNRS campus in Orléans, having been promoted to directeur de recherche. In 2000 he became full professor of psychiatry at the University of Massachusetts Medical School in Worcester, Massachusetts, returning to the CNRS in 2005 as a group leader in the Centre de Neurosciences Intégratives et Cognitives in Talence, a suburb of Bordeaux. He is currently adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine and the chief consultant for Mouse Behavior Consulting Group.
Hippocampal mossy fibers
Together with Herbert Schwegler and Hans-Peter Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learn better, could be found for spatial learning in a radial arm maze task. Taken together, Crusio and collaborators think that it is highly likely that this correlation is causal, although this is not universally accepted.
Mouse model of depression
When mice are exposed to unpredictable chronic mild stress (UCMS), they start exhibiting symptoms reminiscent of major depressive disorder in humans. As it had been suggested that deficits in hippocampal neurogenesis might underlie depression, Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels of aggression, anxiety, depressive-like behaviors, and learning, with a concomitant drop in neurogenesis. However, the results were strain- and sex-specific and there did not appear to be a clear-cut correlation between the different changes, so that they finally concluded that although their data do not disprove the idea that deficits in hippocampal neurogenesis solely underlie the behavioral impairments observed in human psychiatric disorders such as depression, they do not provide support for this hypothesis either.
Mouse model of autism
More recently, Crusio has been investigating the possibility that Fmr1 knockout mice might perhaps be used as a model for autism. This idea is based on the fact that patients suffering from the Fragile X syndrome, caused by a deficiency of the FMR1 gene often show autistic symptoms. A good mouse model for the Fragile X syndrome is available in the form of mice in which the Fmr1 gene (the mouse homologue of the human FMR1 gene) has been invalidated. A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms, especially changes in social behavior, a key symptom of autism.
Crusio is the founding editor-in-chief of Genes, Brain and Behavior, which he edited from 2001 to 2011. The standards for the publication of mouse mutant studies that he and his co-editors developed for this journal are gradually being accepted in the field. Since 2017, Crusio is the editor-in-chief of Behavioral and Brain Functions. He is also an academic editor of PLoS ONE and served as associate editor of Behavioral and Brain Sciences (1991–2008) and The Scientific World Journal (2002-2011). Crusio serves or has served on the editorial boards of Behavioral and Brain Functions, Behavior Genetics (1991–1995), Behavioural Brain Research (1997–2007), BMC Neuroscience, BMC Research Notes, Frontiers in Behavioral Neuroscience, Journal of Visualized Experiments, Molecular Brain (2012-2017), Neurogenetics (1998–2006), Physiology and Behavior, and Current Opinion in Behavioral Sciences. He edited special issues for the journals Behavior Genetics, Behavioural Brain Research, Physiology and Behavior (with Robert Gerlai), Hippocampus (with Aryeh Routtenberg), and Brain Research Bulletin (with Catherine Belzung and Robert Gerlai). Together with Robert Gerlai he also edited a handbook on molecular genetic techniques for behavioral neuroscience. Currently, he is editing the Cambridge Handbooks in Behavioral Genetics, a series of handbooks published by Cambridge University Press, of which the first volume, Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, appeared in 2013. Since then, two more volumes have appeared.
In 1996, Crusio was one of two co-founders of the International Behavioural and Neural Genetics Society, for which he served as member-at-large of the executive committee, treasurer, and president (1998–2001). In 2011 he received from this society the "Distinguished Service Award", which is given for exceptional contributions to the field of behavioral neurogenetics. Crusio also served on the executive committees of the Behavior Genetics Association (from which he resigned in protest to Glayde Whitney's 1995 presidential address), the European Brain and Behaviour Society, and the International Behavioral Neuroscience Society, and has been a President of the Dutch Behavior Genetics Contact Group. He has been a member of several program committees for scientific meetings, most notably the 8th and 10th World Congresses of Psychiatric Genetics and the 2008, 2009 (co-chair), 2010 (chair), and 2011 (chair) Annual Meetings of the IBNS.
- Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (2007). "A quantitative-genetic analysis of hippocampal variation in the mouse". Journal of Neurogenetics. 21 (4; Special Retrospective Issue: The Origins of Neurogenetics): 197–208. doi:10.1080/01677060701715827. PMID 18161583. Original publication: Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (July 1986). "A quantitative-genetic analysis of hippocampal variation in the mouse". Journal of Neurogenetics. 3 (4): 203–214. doi:10.3109/01677068609106850. PMID 3746523.
- Crusio, W. E.; Schwegler, H.; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution". Brain Research. 425 (1): 182–185. doi:10.1016/0006-8993(87)90498-7. PMID 3427419.
- Crusio, W. E.; Schwegler, H.; van Abeelen, J. H. F. (February 1989). "Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis". Behavioural Brain Research. 32 (1): 81–88. doi:10.1016/S0166-4328(89)80075-0. PMID 2930637.
- Crusio W. E. (November 2001). "Genetic dissection of mouse exploratory behaviour". Behavioural Brain Research. 125 (1–2): 127–132. doi:10.1016/S0166-4328(01)00280-7. PMID 11682103.
- Crusio, W. E.; Goldowitz, D.; Holmes, A.; Wolfer, D. (February 2009). "Standards for the publication of mouse mutant studies". Genes, Brain and Behavior. 8 (1): 1–4. doi:10.1111/j.1601-183X.2008.00438.x. PMID 18778401.
- "Wim E. Crusio Curriculum Vitae" (PDF). Wim E. Crusio Blog. February 2016.
- Brünner, Gerhard (1987). "Crusio, Wim: Die Gattung Anubias (Araceae)". Für Ihre Bücherei. Aquarien Magazin (in German). 21 (7).
- Klix, Wolf-Dieter (2009). "Protokoll der Mitgliederversammlung 2009 des Arbeitskreises Wasserpflanzen in Dresden". Aqua Planta (in German). 34 (4): 150–151. Retrieved 2010-08-22.
Announcement of re-issue on CD of 1987 German edition of Anubias revision
- Crusio, WE (1984). Olfaction and behavioral responses to novelty in mice: A quantitative-genetic analysis. Meppel: Krips Repro. pp. viii+146+78.
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- "Publications by Humboldt Research Fellows from abroad in 2005: Biosciences, Life Sciences". Retrieved 2009-08-11.
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- "Our Team". mousebehavior.com. Retrieved 2017-09-28.
- Crusio, W. E.; Schwegler, H; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution". Brain Research. 425 (1): 182–185. doi:10.1016/0006-8993(87)90498-7. PMID 3427419. Retrieved 2009-08-14.
- Schwegler, H; Crusio, W. E.; Brust, I (1990). "Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory". Neuroscience. 34 (2): 293–298. doi:10.1016/0306-4522(90)90139-U. PMID 2333144. Retrieved 2009-08-14.
- Crawley, Jacqueline (2007). What's Wrong With My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice. John Wiley & Sons. p. 138. ISBN 9780470119044.
- Crusio, W. E.; Schwegler, H (April 2005). "Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice". Behavioral and Brain Functions. 1 (3): 1–11. doi:10.1186/1744-9081-1-3. PMC . PMID 15916698.
- Morris, R. (2007). "Theories of hippocampal function". In Andersen, P.; Morris, R.; Amaral, D.; Bliss, T.; O'Keefe, J. The Hippocampus Book. Oxford, UK: Oxford University Press. pp. 581–713. ISBN 978-0-19-510027-3.
- Willner P (December 1997). "Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation". Psychopharmacology. 134 (4): 319–329. doi:10.1007/s002130050456. PMID 9452163. Retrieved 2009-08-15.
- Kempermann, G; Kronenberg, G (September 2003). "Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression". Biological Psychiatry. 54 (5): 499–503. doi:10.1016/S0006-3223(03)00319-6. PMID 12946878. Retrieved 2009-08-15.
- Mineur, Y. S.; Prasol, D. J.; Belzung, C; Crusio, W. E. (September 2003). "Agonistic behavior and unpredictable chronic mild stress in mice" (PDF). Behavior Genetics. 33 (5): 513–519. doi:10.1023/A:1025770616068. PMID 14574128. Retrieved 2009-08-16.
- Mineur, Y. S.; Belzung, C; Crusio, W. E. (November 2006). "Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice". Behavioural Brain Research. 175 (1): 43–50. doi:10.1016/j.bbr.2006.07.029. PMID 17023061.
- Wahlsten, Douglas (2010). Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience. Academic Press. p. 166. ISBN 9780123756756.
- Mineur, Y. S.; Belzung, C; Crusio, W. E. (December 2007). "Functional implications of decreases in neurogenesis following chronic mild stress in mice". Neuroscience. 150 (2): 251–259. doi:10.1016/j.neuroscience.2007.09.045. PMID 17981399.
- The Dutch-Belgian Fragile X Consortium (July 1994). "Fmr1 knockout mice: a model to study fragile X mental retardation". Cell. 78 (1): 23–33. doi:10.1016/0092-8674(94)90569-X. PMID 8033209. Retrieved 2009-08-15.
- Bernardet, M; Crusio, W. E. (2006). "Fmr1 KO mice as a possible model of autistic features". The Scientific World Journal. 6: 1164–1176. doi:10.1100/tsw.2006.220. PMID 16998604.
- Mineur, Y. S.; Huynh, L. X.; Crusio, W. E. (March 2006). "Social behavior deficits in the Fmr1 mutant mouse". Behavioural Brain Research. 168 (1): 172–175. doi:10.1016/j.bbr.2005.11.004. PMID 16343653.
- Spencer, C. M.; Alekseyenko, O; Serysheva, E; Yuva-Paylor, L. A.; Paylor, R (October 2005). "Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome". Genes, Brain and Behavior. 4 (7): 420–430. doi:10.1111/j.1601-183X.2005.00123.x. PMID 16176388.
- Pagel, Mark (7 May 2004). "The order in a billion sequences". Times Higher Education. Retrieved 2010-07-09.
- Crusio, W. E.; Goldowitz, D; Holmes, A; Wolfer, D (February 2009). "Standards for the publication of mouse mutant studies". Genes, Brain and Behavior. 8 (1): 1–4. doi:10.1111/j.1601-183X.2008.00438.x. PMID 18778401.
- "Author Guidelines". European Journal of Neuroscience. doi:10.1111/(ISSN)1460-9568. Retrieved 2009-08-30.
- Editorial (September 2009). "Troublesome variability in mouse studies". Nature Neuroscience. 12 (9): 1075. doi:10.1038/nn0909-1075. PMID 19710643. Retrieved 2009-08-30.
- "Editorial Board". Behavioral and Brain Functions. BioMed Central. Retrieved 2017-08-25.
- Crusio, Wim E. (September 1996). Crusio WE, ed. "Special issue: The neurobehavioral genetics of aggression". Behavior Genetics. 26 (5): 459–504. doi:10.1007/BF02359749. Retrieved 2009-08-14.
- Crusio WE, ed. (September 1998). "Special issue: The genetic dissection of brain-behaviour relationships: An introduction to neurobehavioural genetics". Behavioural Brain Research. 95 (1): 1–142. doi:10.1016/S0166-4328(97)00203-9. Retrieved 2009-08-14.
- Gerlai RT, Crusio WE, eds. (August 2001). "Special issue: Bridging the gap from gene to behavior: Recombinant DNA techniques merge with behavioral neurobiology". Physiology and Behavior. 73 (5): 671–886. doi:10.1016/S0031-9384(01)00583-2. Retrieved 2009-08-14.
- Routtenberg A, Crusio WE, eds. (February 2001). "Special Issue: Gene Targeting and Hippocampal Function". Hippocampus. 12 (1): 1–108. doi:10.1002/hipo.10001. Retrieved 2009-08-14.
- Belzung C, Crusio WE, Gerlai RT, eds. (January 2002). "Special issue: Behavioral neurogenetics, the genetic dissection of brain and behavior". Brain Research Bulletin. 57 (1): 1–131. doi:10.1016/S0361-9230(01)00629-3. PMID 11827730. Retrieved 2009-08-14.
- Crusio, WE; Gerlai, RT (1999). Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. Amsterdam: Elsevier. pp. xxvii+965. ISBN 0-444-50239-4.
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- Skoulakis, Efthimios M.C. (2001). "A tool for synthesis". Trends in Neurosciences. 24 (2): 127. doi:10.1016/S0166-2236(00)01670-2. Reprinted in: Skoulakis, Efthimios M.C (2001). "A tool for synthesis". Trends in Molecular Medicine. 7 (3): 139. doi:10.1016/S1471-4914(01)01956-6.
- "Series - Cambridge Handbooks in Behavioral Genetics". Cambridge University Press. Retrieved 2012-11-25.
- Mandillo, Silvia (2014). "Book review: Behavioral Genetics of the Mouse". Genes, Brain and Behavior. 13 (5): 517. doi:10.1111/gbb.12125.
- Michetti, Caterina (2014). "BEHAVIORAL GENETICS OF THE MOUSE. Genetics of Behavioral Phenotypes. Volume 1" (PDF). Annali dell'Istituto Superiore di Sanità. 50 (4): 378–379. doi:10.4415/ANN_14_04_14.
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