Commodities carried by the railroad are grain, sand, gravel, stone, forest products, paper products, coal, coke, cement, clay fertilizer, aluminum, chemicals, iron, and steel. Principal shippers are Corn Products Company of Winston-Salem, a manufacturer of corn syrup and related products, and Owens Brockway Glass Company of Eller, a manufacturer of glass products.
On April 16, 2010, notice was published of the intent to merge the High Point, Thomasville, and Denton Railroad into the Winston-Salem Southbound Railway, effective May 1, 2010.
The WSS used a variety of steam locomotives from 1910 until 1957, since the Norfolk and Western Railway continued to operate with steam engines, so there was no hurry to dieselize the Winston-Salem Southbound Railway. A new day dawned on April 22, 1957, when four new EMD GP9 diesels arrived, priced at about $190,000 each. With diesels in full command, the handmaidens of steam engines, the water tanks and coaling stations would soon fall, as did the dark smudges of coal smoke. The 4 GP9s that were purchased were from N&W and ACL, the two companies that owned the WSS. They were re-painted into two different paint schemes and served from the 1950s to the late 1960s, when the WSS, realizing it wasn't cost-effective to maintain servicing facilities, sent the GP9s back to their respective owners and started to lease equipment from the ACL and N&W. To this day, the WSS continues to lease road power from the successors of the ACL (CSX) and N&W (NS). GP9 units: 1501 (N&W), 1502 (N&W), 1503 (ACL), 1504 (ACL)