Born in Szczuczyn he was a descendant on his father's side from at least eight generations of rabbis. Gold's first teacher was his maternal grandfather, Rabbi Yehoshuah Goldwasser. Later he studied at the Mir yeshiva under Rabbi Eliyahu Baruch Kamei. From there Gold moved on to study in Lida at Yeshiva Torah Vo'Da'as - the yeshiva of Rabbi Yitzchak Yaacov Reines where Torah was combined with secular studies. Gold was ordained as a Rabbi at the age of 17 by Rabbi Eliezer Rabinowitz of Minsk, and succeeded his father-in-law Rabbi Moshe Reichler, as rabbi in Juteka.
At the age of 18, he moved to the United States, where he served as rabbi in several communities including South Chicago, Scranton, Pennsylvania (until 1912), Congregation Beth Jacob Ohev Sholom in Williamsburg, Brooklyn (1912–1919), San Francisco (until 1924) and Congregation Shomrei Emunah of Borough Park, Brooklyn (1928-1935). 
He was a pioneer in establishing Orthodox Judaism in the United States. He founded the Williamsburg Talmud Torah, and in 1917 founded Yeshiva Torah Vodaas. He started the Beth Moshe hospital and an orphanage in Brooklyn and also founded a Hebrew teachers training college in San Francisco.
In 1914, Rabbi Gold invited Rabbi Meir Berlin, secretary of the World Mizrachi, to come to New York to organize a branch of Mizrachi in the United States. For the next 40 years, Rabbi Gold traveled throughout the United States and Canada organizing chapters of the Mizrachi movement and became president of American Mizrachi in 1932.
In 1935, he emigrated to Palestine, where he became the head of the Department of Torah Education and Culture in the Diaspora in which capacity he was instrumental in establishing new educational institutions within the Diaspora, devoting himself particularly to the educational needs of North African Jewry.
During World War II, he was involved in the widespread Zionist opposition to the British White Paper of 1939 and worked to rescue European Jewry from the Holocaust. In 1943, he traveled to the United States where he participated as a speaker on behalf of European Jewry at the Rabbis' march in Washington.
He was a member of the Jewish Agency Executive, heading the Department for Jerusalem Development.
On 8 April 1956, Rabbi Gold died in Jerusalem and was buried near his lifelong friend Rabbi Meir Berlin.
- אנציקלופדיה לחלוצי הישוב ובוניה, Vol. 4, page 1873
- Abelow, Samuel P., "The Jews of Williamsburg", in Hurwitz, Solomon Theodore Halivy. The Jewish Forum: A Monthly Magazine, Volume 31, The Jewish Forum Publishing Co., 1948, p. 198.
- Sherman, Moshe D. Orthodox Judaism in America: A Biographical Dictionary and Sourcebook, Greenwood Publishing Group, 1996, p. 78.
- Summer, Morton, "Synagogue and Community In Boro Park". Yeshiva College Yearbook - Masmid, 1954, p. 83
- "Rabbi Installed in Temple Here". bklyn.newspapers.com. Newspapers.com. May 21, 1928. Retrieved Feb 5, 2018.
- Encyclopaedia Judaica. 7. Keter Publishing. 1972. p. 697.
- Bunim, Amos (1989). A Fire in His Soul: Irving M. Bunim, 1901-1980, the Man and His Impact on American Orthodox Jewry. Feldheim Publishers. p. 250. ISBN 0873064739.
- Frand, Yissocher; Rosenblum, Yonason (1995). Rabbi Yissocher Frand in Print: Contemporary and Classic Issues Through the Prism of Torah. Mesorah Publications Ltd. pp. 218–219. ISBN 0899066313.
- Moshe Sherman, Orthodox Judaism in America, (Ct. 1996), pp. 78-79.
- The Signatories of the Declaration of the Establishment of the State of Israel Jewish Virtual Library
- The History of Machon Gold Machon Gold