Transverse section of a chick embryo of forty-five hours' incubation.
|Gives rise to||vas deferens, seminal vesicles, epididymis|
|Latin||ductus mesonephricus; ductus Wolffi|
The mesonephric duct (also known as Wolffian duct, archinephric duct, Leydig's duct and nephric duct) is a paired organ found in mammals including humans during embryogenesis. Wolffian structures are male urogenital structures that include the epididymis, vas deferens, and seminal vesicles that differentiate from this structure.
In both the male and the female the Wolffian duct develops into the trigone of urinary bladder, a part of the bladder wall. However, further development differentiates between the sexes in the development of the urinary and reproductive organs.
In a male, it develops into a system of connected organs between the efferent ducts of the testis and the prostate, namely the epididymis, the vas deferens, and the seminal vesicle. The prostate forms from the urogenital sinus and the efferent ducts form from the mesonephric tubules.
For this it is critical that the ducts are exposed to testosterone during embryogenesis. Testosterone binds to and activates androgen receptor, affecting intracellular signals and modifying the expression of numerous genes.
In the female, with the absence of anti-Müllerian hormone secretion by the Sertoli cells and subsequent Müllerian apoptosis, the Wolffian duct regresses, and inclusions may persist. The epoophoron and Skene's glands may be present. Also, lateral to the wall of the vagina a Gartner's duct or cyst could develop as a remnant.
- Fetal genital development
- List of homologues of the human reproductive system
- Müllerian duct
- Sexual differentiation
- Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA (2006). "Changes in gene expression during Wolffian duct development". Horm. Res. 65 (4): 200–9. doi:10.1159/000092408. PMID 16567946.
- synd/2845 at Who Named It?
- MedicalMnemonics.com: 1266
- How the Body Works / Sex Development / Sexual Differentiation / Duct Differentiation - The Hospital for Sick Children (GTA - Toronto, Ontario, Canada)