It was a railway station and had a post office between 1901 and 1936. It was named after explorer Nathaniel J. Wyeth, builder of Fort Hall (today's Pocatello, Idaho) and the Fort William trading post on Sauvie Island. The area is now home to the Wyeth State Recreation Area.
Wyeth is located 15 miles west of Hood River, Oregon at exit #51 of I-84, and 1/4 mile west on Herman Creek Road. It is a trailhead for Wyeth Trail #411, the Gorge Trail #400, and Gorton Creek Falls.
Wyeth was an early settlement site. It became the site of a Civilian Conservation Corps (CCC) camp in the 1930s. In the 1940s, it was the site of Camp 21, a Civilian Public Service camp for Conscientious Objectors that took over the abandoned CCC facility during World War II. Residents of the camp included architect Kemper Nomland, actor Lew Ayres, politician George Brown, Jr., and actor, director and playwright Kermit Sheets.
- "Wyeth". Geographic Names Information System. United States Geological Survey. November 28, 1980. Retrieved 2010-02-25.
- McArthur, Lewis A.; McArthur, Lewis L. (2003) . Oregon Geographic Names (7th ed.). Portland, Oregon: Oregon Historical Society Press. pp. 1060–1061. ISBN 978-0875952772.
- Wyeth Columbia River Images
- Wyeth Columbia River Gorge National Scenic Area
- Charles Davis and Jeffrey Kovac Confrontation at the Locks; A Protest of Japanese Removal and Incarceration during World War II, Oregon Historical Quarterly
- Jeffrey Kovac, Refusing War, Affirming Peace: A History of Civilian Public Service Camp #21 at Cascade Locks, Oregon State University Press, 2009