Wynne currently works out of Seattle, Washington. She attended Douglass College, and Rutgers University for her undergraduate studies and later received an MFA from the Milton Avery Graduate School for the Arts, Bard College in 2004.
Wynne is best known for her work under the name Tracy + the Plastics. While working as the Plastics, Wynne played the role of three characters: Tracy and her back-up singers Nikki Romanos and Cola. In live performances, Nikki and Cola (aka "the Plastics") existed in pre-recorded video which played behind Tracy as she gave live vocals. The project ended in June 2006.
In 2005, Wynne and fellow artist K8 Hardy collaborated on the New Report, a video piece in which the two played reporters on a fictional feminist news station. The film combines activism and campy satire, critiquing the absurdity of televised news. It was part of the Tate Modern Level 2: Media Burn exhibition.
Her installation entitled "Peas" was featured as a Susanne Vielmetter Berlin Project from February to April 2007.
In 2008, Wynne received a Genius Award from Seattle's The Stranger (newspaper), which included a check for $5,000 and a notification via cake. The cake was received while Wynne was teaching art to kids convicted of crimes at Southeast Youth and Family Services in Columbia City. She responded to the honor by saying, "You have no idea what this means. . . . Now I can make art again.” 
In 2012, Wynne released a full-length music album titled A Fire to Keep You Warm
Other locations that Wynne's work has been shown are The Moore Space, Miami; Participant, New York; Susanne Vielmetter Los Angeles Projects, Los Angeles; The Hayward, London, UK; the Frye Art Museum, Seattle, WA; Reena Spaulings Fine Arts, New York; Foxy Productions, New York; The Kitchen, New York; and the Moscow Biennale. Group exhibitions and performances include New Report, The F Word, Andy Warhol Museum, Pittsburgh, PA; Tracy + the Plastics, TBA Festival, Portland Institute of Contemporary Art, Portland, OR; Tracy + the Plastics, Walker Art Center, Minneapolis, MN; What is Human?, Transmodern Age Festival of Experimental Performance, Baltimore, MD; Tracy + the Plastics, Whitney Biennial, New York; and Hot Topic and On the Verge, videos for Le Tigre live performance, world tour 2004-2005.
- Wynne Greenwood - Susanne Vielmetter Los Angeles Projects
- Jared, Pappas-Kelley (2008-01-24). "Wynne Greenwood of Tracy + the Plastics talks about her installation at the Tollbooth Gallery". Retrieved 2008-01-27.
- Whitney Biennial Artist, Wynne Greenwood Exhibits and Performs as Tracy and the Plastics in TACOMA
- Level 2 Gallery: Media Burn: Wynne Greenwood and K8 Hardy
- http://slog.thestranger.com/2008/07/the_2008_genius_awards_the_cake_episode Wynne receives Genius Award
- Greenwood, Wynne. "Wynne Greenwood". WynneGreenwood.com. Retrieved April 12, 2016.
- Susanne Vielmetter Los Angeles Projects