X-His dipeptidase

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Xaa-His dipeptidase
EC number3.4.13.3
CAS number9027-21-8
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Xaa-His dipeptidase (EC, aminoacylhistidine dipeptidase, carnosinase, homocarnosinase, dipeptidase M) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of Xaa!His dipeptides

This mammalian cytosolic enzyme also acts on anserine and homocarnosine.


  1. ^ Hanson HT, Smith EL (June 1949). "Carnosinase; an enzyme of swine kidney". The Journal of Biological Chemistry. 179 (2): 789–801. PMID 18150012.
  2. ^ Rosenberg A (December 1960). "The activation of carnosinase by divalent metal ions". Biochimica et Biophysica Acta. 45: 297–316. doi:10.1016/0006-3002(60)91454-2. PMID 13743376.
  3. ^ Lenney JF, Kan SC, Siu K, Sugiyama GH (November 1977). "Homocarnosinase: a hog kidney dipeptidase with a broader specificity than carnosinase". Archives of Biochemistry and Biophysics. 184 (1): 257–66. doi:10.1016/0003-9861(77)90349-6. PMID 21630.
  4. ^ Lenney JF (May 1990). "Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase)". Biological Chemistry Hoppe-Seyler. 371 (5): 433–40. doi:10.1515/bchm3.1990.371.1.433. PMID 2378680.

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