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X12 or X-12 may refer to:
- ASC X12, the standard for the development and maintenance of Electronic Data Interchange standards for the United States
- Convair X-12, an advanced testbed for the Atlas rocket program
- X-12-ARIMA, software for seasonal adjustment of time series data
- SJ X12, a Swedish train.
- X-12, a proposed American nuclear-powered locomotive.
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