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Chemokine (C motif) receptor 1
Symbols XCR1 ; CCXCR1; GPR5
External IDs OMIM600552 MGI1346338 HomoloGene21095 IUPHAR: 75 ChEMBL: 4339 GeneCards: XCR1 Gene
RNA expression pattern
PBB GE XCR1 221468 at tn.png
More reference expression data
Species Human Mouse
Entrez 2829 23832
Ensembl ENSG00000173578 ENSMUSG00000060509
UniProt P46094 Q9R0M1
RefSeq (mRNA) NM_001024644 NM_011798
RefSeq (protein) NP_001019815 NP_035928
Location (UCSC) Chr 3:
46.02 – 46.03 Mb
Chr 9:
123.85 – 123.86 Mb
PubMed search [1] [2]

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]


External links[edit]

  • "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.