XCR1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
XCR1
Identifiers
Aliases XCR1, CCGPR5, X-C motif chemokine receptor 1
External IDs MGI: 1346338 HomoloGene: 21095 GeneCards: 2829
RNA expression pattern
PBB GE XCR1 221468 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005283
NM_001024644

NM_011798

RefSeq (protein)

NP_001019815.1
NP_005274.1

n/a

Location (UCSC) Chr 3: 46.02 – 46.03 Mb Chr 9: 123.85 – 123.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

References[edit]

External links[edit]

  • "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.