XJB-5-131

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XJB-5-131
line drawing of XJB-5-131
Legal status
Legal status
  • experimental
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC53H80N7O9
Molar mass959.26 g·mol−1
3D model (JSmol)

XJB-5-131 is a synthetic antioxidant. In a mouse model of Huntington's disease, it has been shown to reduce oxidative damage to mitochondrial DNA, and to maintain mitochondrial DNA copy number.[1] XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death.[2]

References[edit]

  1. ^ Xun, Z; Rivera-Sánchez, S; Ayala-Peña, S; Lim, J; Budworth, H; Skoda, EM; Robbins, PD; Niedernhofer, LJ; Wipf, P; McMurray, CT (2012). "Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease". Cell Rep. 2 (5): 1137–42. doi:10.1016/j.celrep.2012.10.001. PMC 3513647. PMID 23122961.
  2. ^ Krainz, Tanja; Gaschler, Michael; Lim, Chaemin; Sacher, Joshua; Stockwell, Brent; Wipf, Peter (September 7, 2016). "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis". ACS Central Science. 2 (9): 653–659. doi:10.1021/acscentsci.6b00199. PMC 5043442. PMID 27725964.