XRN1 (gene)

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XRN1
Identifiers
Aliases XRN1, SEP1, 5'-3' exoribonuclease 1
External IDs MGI: 891964 HomoloGene: 5894 GeneCards: XRN1
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for XRN1
Genomic location for XRN1
Band 3q23 Start 142,306,607 bp[1]
End 142,448,062 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042604
NM_001282857
NM_001282859
NM_019001

NM_011916
NM_001311130

RefSeq (protein)

NP_001269786
NP_001269788
NP_061874

n/a

Location (UCSC) Chr 3: 142.31 – 142.45 Mb Chr 9: 95.95 – 96.06 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5’ to 3’ direction.[5][6]

Function[edit]

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.