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YES proto-oncogene 1, Src family tyrosine kinase
Protein YES1 PDB 2hda.png
PDB rendering based on 2hda.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols YES1 ; HsT441; P61-YES; Yes; c-yes
External IDs OMIM164880 MGI99147 HomoloGene55900 ChEMBL: 2073 GeneCards: YES1 Gene
EC number
RNA expression pattern
PBB GE YES1 202933 s at tn.png
PBB GE YES1 202932 at tn.png
More reference expression data
Species Human Mouse
Entrez 7525 22612
Ensembl ENSG00000176105 ENSMUSG00000014932
UniProt P07947 Q04736
RefSeq (mRNA) NM_005433 NM_001205132
RefSeq (protein) NP_005424 NP_001192061
Location (UCSC) Chr 18:
0.72 – 0.81 Mb
Chr 5:
32.61 – 32.69 Mb
PubMed search [1] [2]

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.[1][2]

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.[2]


YES1 has been shown to interact with Janus kinase 2,[3] CTNND1,[4] RPL10[5] and Occludin.[6]


  1. ^ Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science 227 (4690): 1038–40. doi:10.1126/science.2983418. PMID 2983418. 
  2. ^ a b "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1". 
  3. ^ Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. (UNITED STATES) 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385. 
  4. ^ Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. (United States) 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114. 
  5. ^ Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. (United States) 277 (39): 36489–98. doi:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090. 
  6. ^ Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell (United States) 13 (4): 1227–37. doi:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934. 

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