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AliasesYIPF6, FinGER6, Yip1 domain family member 6
External IDsMGI: 1925179 HomoloGene: 15501 GeneCards: YIPF6
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for YIPF6
Genomic location for YIPF6
BandXq12-q13.1Start68,498,323 bp[1]
End68,537,285 bp[1]
RNA expression pattern
PBB GE YIPF6 212340 at fs.png

PBB GE YIPF6 212342 at fs.png

PBB GE YIPF6 212341 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 68.5 – 68.54 MbChr X: 98.94 – 98.95 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Protein YIPF6 is a protein that in humans is encoded by the YIPF6 gene.[5][6]

In mice, a null allele of YIPF6 has been found to cause intestinal inflammation resulting in spontaneous colitis and ileitis by impairing intestinal homeostasis. The impairment was due to defects in the formation and secretion of large secretory granules from goblet and Paneth cells.[7] Because the X-linked YIPF6 mutation resulted in spontaneous disease, it has been suggested that it may increase susceptibility to inflammatory bowel disease in humans, particularly in males.[7][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181704 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047694 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Strausberg RL, Feingold EA, Grouse LH, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241Freely accessible. PMID 12477932. 
  6. ^ "Entrez Gene: YIPF6 Yip1 domain family, member 6". 
  7. ^ a b Brandl, Katherina; Tomisato, Wataru; Li, Xiaohong; et al. (July 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences. 109 (31): 12650–12655. doi:10.1073/pnas.1210366109. PMC 3412000Freely accessible. PMID 22802641. 
  8. ^ Moresco, Eva Marie Y.; Brandl, Katherina (January 2013). "Linking membrane trafficking and intestinal homeostasis". Tissue Barriers. 1 (1): e23119. doi:10.4161/tisb.23119. PMC 3875636Freely accessible. PMID 24665373. 

Further reading[edit]