YKT6

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YKT6
Identifiers
Aliases YKT6
External IDs MGI: 1927550 HomoloGene: 4778 GeneCards: YKT6
RNA expression pattern
PBB GE YKT6 217784 at fs.png

PBB GE YKT6 217785 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006555

NM_019661

RefSeq (protein)

NP_006546
NP_006546.1

NP_062635.2
NP_062635

Location (UCSC) Chr 7: 44.2 – 44.21 Mb Chr 11: 5.96 – 5.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene.[3][4][5]

Function[edit]

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.[5]

Interactions[edit]

YKT6 has been shown to interact with BET1L.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Veit M (Dec 2004). "The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues". The Biochemical Journal. 384 (Pt 2): 233–7. doi:10.1042/BJ20041474. PMC 1134105Freely accessible. PMID 15479160. 
  4. ^ Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D'Esposito M, Galli T, Filippini F (Dec 2004). "Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators". Trends in Biochemical Sciences. 29 (12): 682–8. doi:10.1016/j.tibs.2004.10.002. PMID 15544955. 
  5. ^ a b "Entrez Gene: YKT6 YKT6 v-SNARE homolog (S. cerevisiae)". 
  6. ^ Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270Freely accessible. PMID 11927603. 
  7. ^ Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961Freely accessible. PMID 12388752. 

Further reading[edit]