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CompTox Dashboard (EPA)
|Molar mass||253.32 g mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YM-31636 is a potent and selective 5-HT3 agonist. Systemic administration of YM-31636 increased the number of fecal pellets in rats, and improves colonic motility. It also increases colonic secretions, but not to the point of inducing diarrhea. In addition, it did not reduce the visceral pain threshold, or increase the intensity of visceral pain. These properties indicate that it could be a useful treatment for constipation.
- Ito, H. (December 2000). "Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro". European Journal of Pharmacology. 409 (2): 195–201. doi:10.1016/S0014-2999(00)00851-7. PMID 11104834.
- Kiso, T. (November 2001). "A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain". European Journal of Pharmacology. 431 (1): 35–41. doi:10.1016/S0014-2999(01)01425-X. PMID 11716840.