ATP-dependent metalloprotease YME1L1 is an enzyme that in humans is encoded by the YME1L1gene.
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Two transcript variants encoding different isoforms have been found for this gene.
Coppola M, Pizzigoni A, Banfi S, et al. (2000). "Identification and characterization of YME1L1, a novel paraplegin-related gene". Genomics66 (1): 48–54. doi:10.1006/geno.2000.6136. PMID10843804.
Shah ZH, Hakkaart GA, Arku B, et al. (2000). "The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant". FEBS Lett.478 (3): 267–70. doi:10.1016/S0014-5793(00)01859-7. PMID10930580.
Pellegrini L, Passer BJ, Canelles M, et al. (2001). "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2". Journal of Alzheimer's disease : JAD3 (2): 181–190. PMID12214059.