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Protein YWHAG PDB 2b05.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesYWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56
External IDsMGI: 108109 HomoloGene: 22725 GeneCards: YWHAG
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for YWHAG
Genomic location for YWHAG
Band7q11.23Start76,326,799 bp[1]
End76,358,991 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 76.33 – 76.36 MbChr 5: 135.91 – 135.93 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene.[5][6]

This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.[7]


YWHAG has been shown to interact with C-Raf,[6][8][9] EPB41L3,[8][10] KIF1C[11] and Stratifin.[12]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170027 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051391 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Horie M, Suzuki M, Takahashi E, Tanigami A (September 1999). "Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23". Genomics. 60 (2): 241–3. doi:10.1006/geno.1999.5887. PMID 10486217.
  6. ^ a b Autieri MV, Carbone CJ (July 1999). "14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells". DNA and Cell Biology. 18 (7): 555–64. doi:10.1089/104454999315105. PMID 10433554.
  7. ^ "Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide".
  8. ^ a b Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J (January 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". The Biochemical Journal. 345 Pt 2 (2): 297–306. doi:10.1042/0264-6021:3450297. PMC 1220759. PMID 10620507.
  10. ^ Yu T, Robb VA, Singh V, Gutmann DH, Newsham IF (August 2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". The Biochemical Journal. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMC 1222735. PMID 11996670.
  11. ^ Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.
  12. ^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

Further reading[edit]