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YY1 transcription factor
Protein YY1 PDB 1ubd.png
PDB rendering based on 1ubd.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600013 MGI99150 HomoloGene2556 GeneCards: YY1 Gene
RNA expression pattern
PBB GE YY1 201901 s at tn.png
PBB GE YY1 201902 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7528 22632
Ensembl ENSG00000100811 ENSMUSG00000021264
UniProt P25490 Q00899
RefSeq (mRNA) NM_003403 NM_009537
RefSeq (protein) NP_003394 NP_033563
Location (UCSC) Chr 14:
100.24 – 100.28 Mb
Chr 12:
108.79 – 108.82 Mb
PubMed search [1] [2]

YY1 (Yin Yang 1)[1] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.[2][3]

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.[4]


YY1 has been shown to interact with Histone deacetylase 2,[5][6][7] FKBP3,[8] ATF6,[9] Myc,[10] SAP30,[11] EP300,[6][12] HDAC3,[5][6] NOTCH1[13] and RYBP.[14]


  1. ^ Thiaville, MM; Kim, J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes.". Critical reviews in oncogenesis 16 (3-4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMID 22248054. 
  2. ^ Shi Y, Seto E, Chang LS, Shenk T (November 1991). "Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. 
  3. ^ Zhu W, Lossie AC, Camper SA, Gumucio DL (July 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm Genome 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122. 
  4. ^ "Entrez Gene: YY1 YY1 transcription factor". 
  5. ^ a b Yang, W M; Yao Y L; Sun J M; Davie J R; Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. ISSN 0021-9258. PMID 9346952. 
  6. ^ a b c Yao, Y L; Yang W M; Seto E (September 2001). "Regulation of Transcription Factor YY1 by Acetylation and Deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91. doi:10.1128/MCB.21.17.5979-5991.2001. ISSN 0270-7306. PMC 87316. PMID 11486036. 
  7. ^ Kalenik, J L; Chen D; Bradley M E; Chen S J; Lee T C (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. (ENGLAND) 25 (4): 843–9. doi:10.1093/nar/25.4.843. ISSN 0305-1048. PMC 146511. PMID 9016636. 
  8. ^ Yang, W M; Yao Y L; Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945. 
  9. ^ Li, M; Baumeister P; Roy B; Phan T; Foti D; Luo S; Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. ISSN 0270-7306. PMC 85959. PMID 10866666. 
  10. ^ Shrivastava, A; Saleque S; Kalpana G V; Artandi S; Goff S P; Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science (UNITED STATES) 262 (5141): 1889–92. doi:10.1126/science.8266081. ISSN 0036-8075. PMID 8266081. 
  11. ^ Huang, Nu En; Lin Ching Hui; Lin Young Sun; Yu Winston C Y (June 2003). "Modulation of YY1 activity by SAP30". Biochem. Biophys. Res. Commun. (United States) 306 (1): 267–75. doi:10.1016/S0006-291X(03)00966-5. ISSN 0006-291X. PMID 12788099. 
  12. ^ Lee, J S; Galvin K M; See R H; Eckner R; Livingston D; Moran E; Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. (UNITED STATES) 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. ISSN 0890-9369. PMID 7758944. 
  13. ^ Yeh, Tien-Shun; Lin Yu-Min; Hsieh Rong-Hong; Tseng Min-Jen (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". J. Biol. Chem. (United States) 278 (43): 41963–9. doi:10.1074/jbc.M304353200. ISSN 0021-9258. PMID 12913000. 
  14. ^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680. 

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