|Municipality and town|
Location of the municipality and town of Yarumal in the Antioquia Department of Colombia
|Elevation||2,265 m (7,431 ft)|
|Population (30 June 2005)|
|Time zone||Colombia Standard Time (UTC-5)|
Yarumal is a municipality in the Antioquia Department, Colombia. Yarumal was founded in 1787 as San Luis de Gongora. Municipal status was granted in 1821. The current name of Yarumal comes from a local plant belonging to the Moraceae family, known in botanical Latin as Cecropia peltata L. The municipality (3 parishes and 20 villages) has an area of 724 km², 35,315 inhabitants, and its average elevation is 2,265 m above sea level.
An unusually large proportion of the inhabitants suffer from early-onset Alzheimer's disease, which is caused by a genetic mutation. The genetic mutation is thought to have come from a Spanish conquistador. Approximately 5,000 residents will develop early-onset Alzheimer's. Half of the affected residents were shown to have developed symptoms by their early 40s.
- Lalli, Matthew A.; Cox, Hannah C.; Arcila, Mary L.; Cadavid, Liliana; Moreno, Sonia; Garcia, Gloria; Madrigal, Lucia; Reiman, Eric M.; Arcos-Burgos, Mauricio (2014-10-01). "Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease". Alzheimer's & Dementia 10 (5 Suppl): S277–S283.e10. doi:10.1016/j.jalz.2013.09.005. ISSN 1552-5279. PMC 4019728. PMID 24239249.
- Reitz, Christiane (2015-03-01). "Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities". Expert Review of Molecular Diagnostics 15 (3): 339–348. doi:10.1586/14737159.2015.1002469. ISSN 1744-8352. PMID 25634383.
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