Municipality and town
Location of the municipality and town of Yarumal in the Antioquia Department of Colombia
|Elevation||2,265 m (7,431 ft)|
(30 June 2005)
|Time zone||UTC-5 (Colombia Standard Time)|
The municipality (3 parishes and 20 villages) has an area of 724 km², 35,315 inhabitants, and its average elevation is 2,265 m above sea level.
It gave its name to the Yarumal Society for the Foreign Missions (M.X.Y./I.M.E.Y.), a Medellin-based Latin Catholic Society of Apostolic Life of Pontifical Right for Men, which despite its name is especially active in Colombian missions.
Yarumal was founded in 1787 as San Luis de Gongora. Municipal status was granted in 1821.
An unusually large proportion of the inhabitants suffer from early-onset Alzheimer's disease, which is caused by the gene mutation E280A. The genetic mutation is thought to have come from a Spanish conquistador. Approximately 5,000 residents will develop early-onset Alzheimer's. Half of the affected residents were shown to have developed symptoms by their early 40s.
- Yarumal climbing salamander, indigenous in Colombia
- Lalli, Matthew A.; Cox, Hannah C.; Arcila, Mary L.; Cadavid, Liliana; Moreno, Sonia; Garcia, Gloria; Madrigal, Lucia; Reiman, Eric M.; Arcos-Burgos, Mauricio (2014-10-01). "Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease". Alzheimer's & Dementia. 10 (5 Suppl): S277–S283.e10. doi:10.1016/j.jalz.2013.09.005. ISSN 1552-5279. PMC 4019728. PMID 24239249.
- Reitz, Christiane (2015-03-01). "Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities". Expert Review of Molecular Diagnostics. 15 (3): 339–348. doi:10.1586/14737159.2015.1002469. ISSN 1744-8352. PMC 4677675. PMID 25634383.
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