Yerba buena is a Spanish term meaning "good herb". It may refer to
- Yerba buena, a number of aromatic plants
- Yerba Buena, Tucumán, the capital of the Yerba Buena Department in the province of Tucumán, Argentina
- Yerba Buena Department, a department of Tucumán Province, Argentina consisting of the city of Yerba Buena and two towns
- Yerbas Buenas, a Chilean town and commune in Linares Province, Maule Region
- Yerba Buena, California, a former town that became San Francisco, California, U.S.
- Yerba Buena High School a high school in San Jose, California
- Yerba Buena Island, an island in the San Francisco Bay
- Yerba Buena (band), a fusion band based in New York City
- Yerba Buena Jazz Band, a Dixieland revival band founded by Lu Watters
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