Yu-Gi-Oh R takes place following Yugi Mutou's victory in the Battle City tournament. Yako Tenma, the protégé' and adopted son of Maximillion Pegasus, decides to avenge his teacher's defeat at the hands of Yugi, believing him to be responsible for Pegasus' alleged death. After taking over KaibaCorp while Seto Kaiba is in the United States, Tenma kidnaps Anzu Mazaki, prompting Yugi and his friend Katsuya Jonouchi to face Tenma's RA Project and the duel professors. Seto Kaiba and his brother Mokuba also come to the scene to rescue the company.
Many of the characters that are exclusive to Yu-Gi-Oh! R have names that are also Intel codenames. Intel codenames in turn are frequently taken from names of cities and towns near Intel factories in Oregon, Washington, and other locations.
Yako Tenma(天馬 夜行,Tenma Yakō?) - The kōhai (protégé) and adopted son (often mistaken, or mistranslated as younger brother) of Pegasus J. Crawford (Maximillion Pegasus in the English version) who wants revenge for Pegasus' defeat.
Tilla Mook(ティラ・ムーク,Tira Mūku?) - The second professor, who plays a vampire-themed deck. Yugi defeats her. She is named after Tillamook, Oregon. "Tillamook" is also a pre-release codename for the Embedded 266 MHz Intel Pentium MMX chip.
Klamath Osler(クラマス・オースラー,Kuramasu Ōsurā?) - The third professor, who has such bad luck. Jonouchi defeats him. He is named after Klamath Falls, Oregon. "Klamath" is also a pre-release codename for the 300 MHz Intel Pentium II chip.
Kirk Dixon(カーク・ディクソン,Kāku Dikuson?) - The fourth professor, who plays a machine-themed deck. Yugi defeats him. "Dixon" is also a pre-release codename for the 333 MHz 1.6V Intel Pentium II chip. His key card Commander Covington (督戦官コヴィントン Tokusenkan Covinton) originates from "Covington" codenamed for the 266 MHz P6 Intel Pentium II chip.
Pete Coppermine(ピート・コパーマイン,Pīto Kopāmain?) - The fifth professor, who plays a mutant-themed deck. Jonouchi defeats him. He is named after the Coppermine River in Oregon. The name of that river was used as a codename for the 866 MHz Flip Chip Pin Grid Array (FCPGA) Pentium III (P3-850) microprocessor, which was released by Intel.
Maico Katou(マイコ･カトウ,Maiko Katō?) a.k.a. Mrs. Maico(ミセス・マイコ,Misesu Maiko?) - The sixth professor, who is an old woman in a wheelchair that plays a forest-themed deck. Yugi defeats her. "Maico" is an alternate romanization of the name "Maiko", but it also refers to a brand of motorcycle. Kato Engineering is a company associated with motorcycles. The name also originates from the "KatMai" chip.
Gekko Tenma(天馬 月行,Tenma Gekkō?) - Yako Tenma's older brother (although only slightly older, since they are identical twins). Gekko wants to stop the RA project. He uses an elf deck. "Gekko" is the name of the microprocessor chip in the Nintendo GameCube.
Mendo Cino(メンド・シーノ,Mendo Shīno?) - Mendo, the seventh professor, uses an insect deck. Jonouchi defeats him. "Mendocino" is also a pre-release codename for the 300 MHz P6 Intel Pentium II Centrino chip.
Willa Mette(ウィラー・メット,Wirā Metto?) - Willa, the eighth professor, plays a White Horns Dragon deck. Kaiba defeats him. Willamette is a river in Oregon and a codename for Intel's 1.5 GHz P7 Pentium IV.
Tedd Banias(テッド・バニアス,Teddo Baniasu?) - Tedd, the ninth professor, duels Gekko. Gekko defeats Tedd. Uses a Beast Deck. Banias is the codename for Intel's first x86 Pentium M chip.
Reiko Kitamori(北森 玲子,Kitamori Reiko?) - Reiko, the tenth professor, duels Jonouchi. Jonouchi defeats Reiko. Uses a Chess/Deck Destruction Deck. Kitamori means northwood in Japanese. Northwood was the codename for the 130 nm version of Intel's Pentium 4 microprocessor.
Depre Scott(デプレ・スコット,Depure Sukotto?) - Scott is the eleventh professor, and another of Pegasus' adopted sons. Yugi defeats Depre. He duels against Yugi using a Universe Deck. Prescott was the codename for the 90 nm version of Intel's Pentium 4 microprocessor.
Richie Merced(リッチー・マーセッド,Ritchī Māseddo?) - Richie is the twelfth professor, and another of Pegasus' adopted sons. He duels Gekkou and wins. Merced was the codename for Itanium, an IA-64 microprocessor developed jointly by Intel and Hewlett-Packard.
Cedar Mill(シｰダｰ・ミｰル,Shīdā Mīru?) - Cedar is the thirteenth professor and, although he is not actually named in the actual manga, dispatched almost offhandedly in a single panel by Yugi's Osiris the Heaven Dragon (Slifer the Sky Dragon in the English version), Cedar is identified in a sketch in the 4th volume of the collected manga. Cedar Mill was the codename for the 65 nm version of Intel's Pentium 4 microprocessor. It is also a play on "Cedar Mills", which is an area in Beaverton, Oregon.
Masumi Momono(百野真澄,Momono Masumi?) - Appears in a special chapter of Yu-Gi-Oh! R. Momono tries to take over the Kame Game Shop owned by Sugoroku Mutou. His key card Tualatin (テュアラティン,Thuarathin?) originates from "Tualatin" codenamed for the 1.266 GHz Flip Chip Pin Grid Array (FCPGA2) Pentium III (P3-850) microprocessor, which was released by Intel.