YybP-ykoY leader

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yybP-ykoY leader
Predicted secondary structure and sequence conservation of yybP-ykoY
Symbol yybP-ykoY
Alt. Symbols SraF
Rfam RF00080
Other data
RNA type Cis-reg; riboswitch
Domain(s) Bacteria
SO 0000233

The yybP-ykoY leader RNA element was originally discovered in E. coli during a large scale screen and was named SraF.[1] This family was later found to exist upstream of related families of protein genes in many bacteria, including the yybP and ykoY genes in B. subtilis. The specific functions of these proteins are unknown, but this structured RNA element may be involved in their genetic regulation as a riboswitch.[2] The yybP-ykoY element was later proposed to be manganese-responsive after another associated family of genes, YebN/MntP, was shown to encode Mn2+ efflux pumps in several bacteria.[3][4][5] Genetic data and a crystal structure confirmed that yybp-ykoY is a manganese riboswitch that directly binds Mn2+[6][7]


  1. ^ Argaman, L; Hershberg R; Vogel J; Bejerano G; Wagner EG; Margalit H; Altuvia S (2001). "Novel small RNA-encoding genes in the intergenic regions of Escherichia coli". Curr Biol. 11 (12): 941–950. PMID 11448770. doi:10.1016/S0960-9822(01)00270-6. 
  2. ^ Barrick, JE; Corbino KA; Winkler WC; Nahvi A; Mandal M; Collins J; Lee M; Roth A; Sudarsan N; Jona I; Wickiser JK; Breaker RR (2004). "New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control". Proc Natl Acad Sci USA. 101 (17): 6421–6426. PMC 404060Freely accessible. PMID 15096624. doi:10.1073/pnas.0308014101. 
  3. ^ Waters, LS; Sandoval, M; Storz, G (Nov 2011). "The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis". J Bacteriol. 193 (21): 5887–5897. PMC 3194919Freely accessible. PMID 21908668. doi:10.1128/jb.05872-11. 
  4. ^ Li, C; Tao, J; Mao, D; He, C (2011). "A novel manganese efflux system, YebN, is required for virulence by Xanthomonas oryzae pv. oryzae". PLOS ONE. 6 (7): e21983. PMC 3136493Freely accessible. PMID 21789199. doi:10.1371/journal.pone.0021983. 
  5. ^ Veyrier, FJ; Boneca, IG; Cellier, MF; Taha, MK (Sep 2011). "A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence". PLoS Pathog. 8 (9): e1002261. doi:10.1371/journal.ppat.1002261. 
  6. ^ Price, IR; Gaballa, A; Ding, F; Helmann, JD; Ke, A (19 March 2015). "Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches". Mol Cell. 57 (6): 1110–1123. doi:10.1016/j.molcel.2015.02.016. 
  7. ^ Dambach, M; Sandoval, M; Updegrove, TB; Anantharaman, V; Aravind, L; Waters, LS; Storz, G (19 March 2015). "The Ubiquitous yybP-ykoY Riboswitch Is a Manganese-Responsive Regulatory Element". Mol Cell. 57 (6): 1099–1109. PMC 4376352Freely accessible. PMID 25794618. doi:10.1016/j.molcel.2015.01.035. 

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