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Available structures
PDBOrtholog search: PDBe RCSB
AliasesZBTB33, ZNF-kaiso, ZNF348, zinc finger and BTB domain containing 33
External IDsOMIM: 300329 MGI: 1927290 HomoloGene: 4931 GeneCards: ZBTB33
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ZBTB33
Genomic location for ZBTB33
BandXq24Start120,250,752 bp[1]
End120,258,398 bp[1]
RNA expression pattern
PBB GE ZBTB33 214631 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 120.25 – 120.26 MbChr X: 38.19 – 38.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.[5] This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[6]


ZBTB33 has been shown to interact with HDAC3,[7] Nuclear receptor co-repressor 1[7] and CTNND1.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177485 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048047 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33".
  6. ^ "ZBTB33 zinc finger and BTB domain containing 33 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-03-22.
  7. ^ a b Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (Sep 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  8. ^ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Molecular and Cellular Biology. 19 (5): 3614–23. doi:10.1128/mcb.19.5.3614. PMC 84161. PMID 10207085.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.